**4. Conclusions**

The aim of this study was to describe separately, with a single test, the effect of chemistry, roughness and SPD microstructure on MSC cell adhesion and proliferation using SMAT on two binary FGMs (Ti-Nb and TA64-Mo).


**Author Contributions:** Results analysis and paper writing; L.W. and T.G.; samples preparation and biological tests, Y.N.; microscopy, M.N.; FGMs analysis, P.L.

**Funding:** This study was supported by the French State through the program "Investment in the Future" operated by the National Research Agency (ANR), referenced by ANR-11-LABX-0008-01 (Labex DAMAS).

**Acknowledgments:** The authors gratefully acknowledge the Labex Damas for its financial support, Catherine Schneider-Maunoury from Irepa Laser for the production of FGM and Natalia De Isla from Imopa laboratory in Nancy (France) for the supervision of biological tests.

**Conflicts of Interest:** The authors declare no conflicts of interest.
