2.2.4. Cocrystallisation by Slow Evaporation

A solution of ITR and TER was prepared by weighing 5.96 mg of the API and 0.70 mg of the coformer to prepare a 2:1 mole/mole mixture of the components. The powders were transferred into a glass vial and solubilized in 10 mL of methanol by sonication in a U300 H ultrasonic bath (Ultrawave, Rumney, UK) to obtain a clear solution. Then, the solution was filtered using a 0.45 μm PTFE syringe filter (Fisher Scientific, Loughborough, UK). Parafilm was used to cover the top of the vial and small holes were pierced to allow for solvent evaporation. The solution was left at room conditions until crystallization occurred.
