2.2.2. Cocrystallisation by Slurrying

In this method, solutions of ITR at 0.74 and 2.20 mg/mL were prepared in methanol (MeOH) and acetone, respectively. Then, a 1 mL aliquot of each solution was transferred to a 1.5 mL glass vial and a quantity of TER was added in a 1:50 API-coformer molar ratio. Then, the hermetically closed vials containing the suspensions were mixed at 50 ◦C for 8 h and thereafter for next 4 days at room temperature using an IKA RT 15 magnetic stirrer (Germany). Afterwards, the slurries were dried at 30 ◦C and 100 mbar in a 3608-6CE vacuum oven (ThermoFisher Scientific ™, Waltham, MA, USA).
