*2.4. Statistical Analysis*

The differences in the dissolution profiles were analyzed by two-way variance analysis (ANOVA) of the area under the curve (AUC), using the Origin Pro 9.0 software package (OriginLab Co., Northampton, MA, USA). Subsequently, a multiple post hoc test (Tukey) was performed with a significance level of 0.05 using the Statgraphics software (Statgraphics Technologies, Inc., The Plains, VA, USA).
