3.2.3. Differential Scanning Calorimetry

The thermograms depicted in Figure 3 show the melting endotherms of the micro and nano co-crystalline material with Tpeak = 106.7 ◦C and 103.1 ◦C respectively. The lower melting temperature and peak broadening for the nano co-crystal is likely due to particle size reduction and is in agreemen<sup>t</sup> with the principles of the Van't Hoff equation [52–54]. In addition, slight peak broadening can be attributed to a loss crystallinity and partial formation of amorphous material during the formation of nanosuspensions [55,56].

**Figure 3.** DSC thermograms depicting the melting endotherm for the micro (black) and nano co-crystal (orange).
