2.2.3. Cocrystallisation by Ball Milling (BM)

A quantity of 300 mg of ITR was weighted and added to an amount of each coformer (oxalic acid, succinic acid and TER) corresponding to a 2:1 API-coformer molar ratio. Then, the powders were transferred to a 25 mL stainless-steel grind jar containing two 15 mm stainless-steel balls. Before grinding, two drops of acetone were added to the powders. The mixtures were ground in two cycles of 10 min at 25 Hz using a Retsch Mixer Mill MM 200 (Haan, Germany).
