3.2.4. Powder X-ray Diffraction

It is apparent from Figure 4 that there is almost a one-to-one agreemen<sup>t</sup> between the diffractograms for the micro and nano co-crystal of 3TC.AZT.H2O. The only differences between the diffractograms relates to differences in the fine structure of the profiles. These differences may be attributed to particle size reduction of the NCC as the smaller the particle size results in broader peaks, which equates to less detail in the fine structure. Differences in the relative intensities of the peaks can be attributed to minor preferred orientation effects [57,58].

**Figure 4.** PXRD diffractograms for the micro (black) and nano co-crystals (orange).

### 3.2.5. Energy Dispersive X-ray Scanning Electron Microscopy (EDX-SEM)

The elemental composition of the nano and micro co-crystal indicates an identical percent composition of the elements present. The summary of elemental composition is summarized in Table 2. The data shows that the micro and nano co-crystal have the same elemental composition.


**Table 2.** Elemental composition of the micro and nano co-crystal.
