2.2.1. Preparation of NTZ Cocrystals

NTZ-GLU and NTZ-SUC cocrystals of 1:1 and 2:1 NTZ:coformer stoichiometric ratio, respectively, were synthetized by the liquid-assisted grinding (LAG) technique as previously reported [8]. Samples of 1.0 g were ground in a Retsch MM400 mixer (Haan, Germany; 0.5 h at 25 Hz) with acetone. The formation of the cocrystalline solid phases was established by comparison of the powder X-ray di ffraction (PXRD) patterns with both experimental and simulated patterns obtained from reported X-ray crystal structures (REFCODES: BREEINM and BRENVIEX).
