*2.2. Methods*

### 2.2.1. Neat Grinding (NG) and Liquid-Assisted Grinding (LG)

For these preparations, 40 mg of ITR and an amount of TER corresponding to 2:1, 1:1 and 1:2 of API-coformer molar ratios were carefully weighted. Afterwards, the compounds were ground for 30 s using an agate mortar and pestle.

For liquid-assisted grinding, two drops of methanol were added to the mixture of powders.
