*5.7. Integration of Several Chronodisruptors*

It is likely that the end result of the impact of several chronodisruptors relates to the integration of the different signaling events. In this regard, there is evidence that chronodisruptors potentially associated with CKD interact between them. Thus, RelB directly binds to the AhR and AhR interacts with dietary clues [81,96]. AhR-deficient mice are protected from high fat diet-induced disruption in metabolic rhythms, exhibiting enhanced insulin sensitivity and glucose tolerance [96].
