*5.2. Light Clues*

In June 2019, a working group convened by the International Agency for Research on Cancer (IARC) concluded that "night shift work" is probably carcinogenic to humans and considered a Group 2A carcinogen [65]. There is very little information on night shift work and CKD. However, in a Korean study, the risk of CKD was two-fold higher in female shift workers than in female non-shift workers, although there were no di fferences in males [66]. In experimental animals, maternal chronic photoperiod shifting during gestation led to kidney gene expression changes in the o ffsprings, including the expression of sodium handling genes subject to circadian rhythms, and higher blood pressure values [27].
