**5. Conclusions**

In our previous studies, the data indicated that an increase in the transcript levels of *RbohD* was induced at a relatively early stage during hypoxic stress; for other hypoxia-inducible RBOHs, such as *RbohA*, *B*, *F*, *G*, and *I*, transcript expressions were also affected by oxygen deprivation but not at a relatively early stage [24]. The involvement of other signaling elements in the complex signaling network associated with oxygen deprivation requires further evaluation.

**Author Contributions:** C.-P.H. conducted experiments and analyzed the data. M.-C.W. helps the statistical analysis and manuscript preparation. C.-Y.Y. conceived, designed research and wrote the manuscript. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by the National Science Council, Taiwan (NSC101-2311-B-005-001) to Chin-Ying Yang.

**Acknowledgments:** We would like to thanks Ching-Hsiu Tsai for his kind help in the instrument assistance of quantitative RT-PCR.

**Conflicts of Interest:** The authors declare that they have no conflict of interest.

#### **References**


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