**Preface to "Design and Application of Biomedical Circuits and Systems"**

Since the appearance of electronics as an enabling technology, circuits and systems have been developed to improve biomedical measurements and design new medical equipment for specific tests in the health field. Diagnosis, therapy, clinical testing, and bio-signal monitoring between other medical tasks are properly and accurately performed using electronic equipment and, today, are considered vital for medical data acquisition tasks. The development of new sensing technologies, biomaterials, microelectronic devices, microfluidic systems, micro-electro-mechanical systems (MEMs), etc., open the window to new biomedical circuits and systems opportunities to measure "better" and also using "alternative" methods to find the relevant information required by teams of physicians and biologists. This Special Issue is mainly devoted to incorporating proposals of bio-sensing signals based on new circuits and systems approaches. In general, it is focused on new bio-signal analog front-end (AFE) circuits; specific circuits development for known and new sensor/sensing approaches; circuits for biomedical signal processing; low-voltage and low-power circuits and their application to implants and wearable devices; circuits and systems for clinical applications; circuits for sensing/actuation in MEM systems, Lab-on-a-Chip (LoC), micro-total-analysis Systems (uTAS); and cell assays and manipulation. Other main topics covered in this Special Issue include circuits for bioimpedance test; capacitive-based circuits, circuits for new sensing devices and microeletrodes; ECG, EEG, EMG, EoG, etc. circuits and systems; circuits for implants and wearable devices; LP/LV circuits in biomedical environments; circuits and systems in clinical applications; circuits for cell, DNA, bacteria, virus assays; and brain interfaces.

> **Alberto Yufera, Gloria Huertas, Belen Calvo** *Editors*
