**5. Conclusions**

In summary, the present study demonstrates that di fferent formulations of n3-PUFAs have a beneficial e ffect on cell viability and proliferation, and are able to restore oxidative induced RPE damage. The protective e ffects of these formulations on RPE cells may translate to e ffective treatments to prevent or delay DR progression, which will become increasingly important with the expected rise in DM prevalence and its associated socioeconomic burden in years to come. Although di fferences between the formulations in our study were small, our results are in accordance with previous reports suggesting that supplements that combine both n3-PUFAs with a higher proportion of EPA might be more beneficial, especially when present in the form of triglycerides or phospholipids. Clinical trials specifically designed to confirm these observations in patients with retinal vascular pathologies are needed.

**Author Contributions:** Conceptualization, P.F.-R., S.R. and A.G.-L.; Data curation, M.H., P.F.-R., L.G.-G., N.I. and S.R.; Formal analysis, M.H., P.F.-R., S.R. and A.G.-L.; Funding acquisition, A.G.-L.; Investigation, M.S.d.V., M.H., J.G.-Z., L.G.-G. and N.I.; Methodology, M.S.d.V., M.H. and S.R.; Project administration, S.R.; Supervision, P.F.-R., S.R. and A.G.-L.; Validation, M.S.d.V., J.G.-Z., P.F.-R. and S.R.; Visualization, M.H., J.G.-Z., P.F.-R. and V.B.-M.; Writing—original draft, M.S.d.V., M.H., J.G.-Z. and V.B.-M.; Writing—review & editing, P.F.-R., S.R. and A.G.-L. All authors have read and agreed to the published version of the manuscript.

**Funding:** The present work was partially funded by Thea Laboratoires and partially supported by RETICS (RD16/0008) from ISCIII, Ministerio de Economía y Competitividad, Spain.

**Acknowledgments:** Authors would like to specially thank the grea<sup>t</sup> technician work of Maite Moreno Orduña, Edurne Albiasu Arteta and Natalia Aguado Pérez.

**Conflicts of Interest:** AGL is a consultant for Bayer, Novartis, Allergan, Thea, and Roche. The rest of the authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
