**6. Patents**

The patent related to this study has been registered in Korea (no. 10-2015-0176274).

**Author Contributions:** Y.S.K. designed the in vitro experiment and wrote the manuscript; J.K. designed the in vivo experiments; I.S.L. confirmed the HPLC chromatogram; C.-S.K., K.J., and Y.M.L. performed the animal experiments; D.H.J. performed the in vitro experiments; G.H.B. identified the herbs; J.S.K. designed all experiments and reviewed the manuscript. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the Korea Institute of Oriental Medicine (grant number K18270 and KSN20134261).

**Conflicts of Interest:** The authors declare no conflict of interest.

**Data Availability:** All data generated or analyzed during this study are included in this published article.
