*2.9. Bioinformatic Analysis*

For gene expression analysis, a heat map was generated using the online tool Heatmapper (http: //www.heatmapper.ca/expression/). Protein-protein interaction was predicted using STRING (v 11.0) (https://www.string-db.org/). Where network edges were defined based on evidence. The minimum required interaction score was kept at minimum confidence of 0.400, with no more than 50 interactors. The active interaction sources were text mining, experimentally proved, database, co-expression data, neighborhood joining, gene fusion, and co-occurrence.
