**5. Conclusions**

The present investigation reported the effect of ZIN against LPS-induced oxidative stress, DNA damage, and cytokine storm on various organs by evaluating the biochemical, inflammatory, oxidant-antioxidant markers, and histopathological changes. ZIN in regulating its preventive effect against systemic inflammation further encourages the need to improve it as a more successful treatment. Since several of the novel, creative approaches to treating sepsis target particular biomarkers, better strategies to improve the effectiveness of these new treatment methods would benefit. The results have demonstrated that LPS-induced toxicity and ZIN protects and balances the oxidant-antioxidant status and regulate the generation of cytokine storm. Therefore, ZIN can be beneficial in MODS.

**Author Contributions:** Conceptualization, A.A. and A.F.W.; Data curation, M.U.R. and M.R.; Investigation, A.F.W.; Methodology, A.F.W. and P.G.M.R.; Project administration, A.F.W.; Software, M.U.R., M.R., O.A. and P.A.; Visualization, O.A.; Writing—original draft, M.U.R. and A.A.; Writing—review and editing, A.F.W., M.R., M.K., P.G.M.R., P.A. and A.A. All authors have read and agreed to the published version of the manuscript.

**Funding:** Deanship of Scientific Research (RG-1438-069), King Saud University.

**Acknowledgments:** The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding this work through Research Group Number (RG-1438-069). The authors also wish to thank RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates, for their support through RAKMHSU-REC-08-2019-F-P.

**Conflicts of Interest:** The authors declare no conflict of interest.
