**8. Conclusions**

The species under study reveal grea<sup>t</sup> economic importance not only in the consumption and marketing of fruits, but also as sources for the extraction of molecules with significant bioactive potential, which can be used as phytotherapeutic agents or as raw materials for the development of new drugs. *T. esculenta* has high concentration of phenolic acids, flavonoids, and terpenes, justifying its antioxidant, anti-tumor, anti-inflammatory and antimicrobial action reported by several studies, lacking studies that investigate toxicity associated with the ingestion of its seeds.

Future studies should perform quantitative analyses and isolation of substances from *B. gaudichaudii*, *G. americana* and *B. antiacantha*, favoring the understanding of the antiproliferative, antimicrobial, anti-inflammatory, neuroprotective, and photosensitizing e ffects associated with their extracts. Therefore, fruits of the Brazilian Cerrado o ffer an immeasurable richness of molecules with biological activity of grea<sup>t</sup> interest to the pharmaceutical and cosmetic industries, in addition to the possibility of marketing of fruits and their by-products. The knowledge of the mechanism of action of substances isolated in these extracts enables correlating concentration, e ffectiveness, desirable and side effects, which is fundamental for the establishment of a therapeutic planning and interventions in case of intoxication.

**Author Contributions:** The article was divided by topics and distributed to each researcher according to their affinity for the themes. All authors contributed equally to the writing and revision of the manuscript. G.R.V.-B.: General guidance for the development of the manuscript; Conceptualization; Investigation; Methodology; Project administration; Software (Making figures); Supervision; Validation; Visualization; Roles/Writing—original draft; Writing—review and editing. A.T.d.C., M.M.P., M.S.C., G.C.B., A.M.M., V.C.R., and S.A.O.: Investigation; Methodology; Validation; Visualization; Roles/Writing—original draft; Writing—review and editing. In addition to what was previously mentioned, all authors made due contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data; or the creation of new software used in the work; or have drafted the work or substantively revised it; has approved the submitted version and; agrees to be personally accountable for the author's own contributions and for ensuring that questions related to the accuracy or integrity of any part of the work, even ones in which the author was not personally involved, are appropriately investigated, resolved, and documented in the literature. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Acknowledgments:** We especially thank the Research Group on Development of Pharmaceutical Products (P&DProFar) for the partnership and support in the development of the manuscript.

**Conflicts of Interest:** The authors declare no conflict of interest.
