*4.1. Chemicals and Reagents*

ZIN (99% pure) and LPS were purchased from Sigma-Aldrich. Biochemical estimation kits like ALT, ALP, AST, BUN, Cr, Urea, and CKMB were obtained from Human diagnostics. Oxidative stress markers MDA (K739), GSH (K464), MPO (K747), and (DNA damage marker) 8-OHdG (K4160) were purchased from (BioVision, Inc. Milpitas, CA, USA). Nitric oxide (NO) was obtained from Booster Bio, USA. Tumor necrosis factor-alpha (TNF-<sup>α</sup>, K1052-100), Interleukin (IL) IL-1β (K4796-100), IL-1α (E4804-100), IL-2 (E4831-100), IL-6 (K4145-100) were procured from (Bio-Vision, Milpitas, CA, USA), IL-10 (MBS355232) and Procalcitonin (PCT, MBS162052), a septic biomarker was purchased from (My BioSource, San Diego, CA, USA). All other chemicals were of analytical grade.
