**2. Methodology**

A scientific literature review regarding the traditional uses, phytochemistry, anti-inflammatory, anti-cancer, antioxidant, and anti-autoimmune disease activities of *T. impetiginosa* was performed using bibliographic databases. Keywords used for this study were 'anti-inflammatory,' '*T. impetiginosa*,' 'Taheebo,' and other names synonymous with Taheebo. Research articles were chosen if they tested a compound isolated from *T. impetiginosa* and investigated the related pharmacological activity. Studies using in vitro assays included inhibition of nitric oxide, oxidative enzymes, or cytokines. In vivo trials were included if they used antigens to induce ear edema, arthritis, or colitis in inflammatory animal models. Websites, articles, and scientific papers were used as sources of information on historical uses, components, taxonomy, and morphology of *T. impetiginosa*. Other sites, including mapchart.net, were used to create a distribution map of *T. impetiginosa.*
