*4.1. Plant Extracts*/*LC-MC Analyses*

The stem bark of cultivated *Mahonia aquifolium* (Pursh) Nutt. was collected in the National Garden park in Panˇcevo, Serbia, in October 2014. The voucher specimen is deposited at the herbarium of the Institute for Medicinal Plants Research "Dr Josif Panˇci´c ", Belgrade (No. 046/14).

Both dry extracts were obtained from air-dried and finely powdered stem bark of cultivated *M. aquifolium*. MAE was extracted with 70% EtOH at room temperature for 24 h (1:5, *w*/*v*), while MAW was prepared by ultrasound-assisted extraction with water (1:10, *w*/*v*) for 30 min. Dry extracts were analyzed by the LC/MS method on Agilent 1200 Series, Agilent Technologies, with a DAD detector on the column Zorbax Eclipse XDB-C18 (RRHT, 50 × 4.6 mm i.d.; 1.8 μm) in combination with 6210 time-of-flight LC/MS system (Agilent Technologies) [14].
