*Tabebuia impetiginosa***: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties**

**Jianmei Zhang 1,**†**, Stephanie Triseptya Hunto 1,**†**, Yoonyong Yang 2, Jongsung Lee 1,\* and Jae Youl Cho 1,\***


Academic Editors: Raffaele Pezzani and Sara Vitalini Received: 29 August 2020; Accepted: 16 September 2020; Published: 18 September 2020

**Abstract:** *Tabebuia impetiginosa*, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from *T. impetiginosa* have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning *T. impetiginosa*, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive search of the published literature was conducted to locate original publications pertaining to *T. impetiginosa* up to June 2020. The main inquiry used the following keywords in various combinations in titles and abstracts: *T. impetiginosa*, Taheebo, traditional uses, phytochemistry, immunopharmacological, anti-inflammatory activity. Immunopharmacological activity described in this paper includes its anti-inflammatory, anti-allergic, anti-autoimmune, and anti-cancer properties. Particularly, *T. impetiginosa* has a strong effect on anti-inflammatory activity. This paper also describes the target pathway underlying how *T. impetiginosa* inhibits the inflammatory response. The need for further investigation to identify other pharmacological activities as well as the exact target proteins of *T. impetiginosa* was also highlighted. *T. impetiginosa* may provide a new strategy for prevention and treatment of many immunological disorders that foster extensive research to identify potential anti-inflammatory and immunomodulatory compounds and fractions as well as to explore the underlying mechanisms of this herb. Further scientific evidence is required for clinical trials on its immunopharmacological effects and safety.

**Keywords:** *Tabebuia impetiginosa*; Taheebo; traditional uses; immunopharmacology; immunological disorders
