Multi-Unit Activity

MUA is an important measure to identify the entrance of the STN. Both through visual and auditory inspection and by automatic identification algorithms, an increase in neuronal activity, compared to the overlying white matter zone, is one of the most widely used signs of the dorsal border of the STN [45]. Our results show that sedatives, either continuous or discontinued, as well as a number of patient specific characteristics, influence MUA. To our knowledge, no previous studies have investigated the e ffect of PSA agents on MUA, despite its usefulness as a clinical marker. More research is necessary to define whether these e ffects are large enough to be clinically relevant.
