*2.8. Statistical Analysis*

All results are reported as mean ± SEM. Percent change from the respective baseline (0 h) value of each visit was calculated to construct the area under the curve (AUC) using the linear trapezoidal integration [34]. All percent change and AUC data were normalized by a log10 conversion before statistical analysis. The mixed model procedure (PROC GLM) was used to test the effects of ASP dose, time point, and their interaction on study outcomes, followed by the Tukey–Kramer honestly significant difference (Tukey's HSD) test. Either paired *t*-test or one-way ANOVA followed by Tukey's HSD test was employed to test the difference between the high ASP dose and control in the AUC data of MDA, F2α-isoprostanes, GSH, GSSG, GSH/GSSG ratio, lag time of LDL oxidation, GPx activity, and ORACpca. Differences with *p* ≤ 0.05 were considered significant. The SAS 9.2 statistical software package (SAS Institute Inc. Cary, NC, USA) was used to perform all statistical analyses.
