**5. Conclusions**

This work provides information on the activity that this flavonoid induces on the reactivity of HSP and its consequences on the oxidative and inflammatory response to favor protection in the structure and function of hippocampal neurons and consequently an improvement in spatial memory. In this sense, it provides some data about flavonoid activity on the molecular mechanism for regulation of these chaperones, which assures cell survival in the Hp of animals intoxicated with Aβ25–35, and which could be soon applied to AD therapy.

**Author Contributions:** A.D. and S.T. designed the study and wrote the protocol. A.D., G.P.-F., S.T., B.E., E.M.-M., and K.R. performed the experiments. A.D., S.T., F.P.-S., S.M., M.R.O., and J.G. managed the literature searches and analysis, F.P.-S. and S.M. undertook the statistical analysis. A.D., S.T., and J.G. wrote the first draft of the manuscript. All contributing authors have approved the final manuscript.

**Funding:** Funding for this study was provided by grants from VIEP-BUAP gran<sup>t</sup> (No. DIFA-NAT18-G) to A.D., (No. TEMS-NAT18-I) to S.T. and PAPIIT-UNAM (IN214117) to J.G. None of the funding institutions had any further role in the study design, the collection of data, analyses and interpretation of data, and writing of the report, or in the decision to submit the paper for publication and interpretation of data.

**Acknowledgments:** We want to thank Enrique Moreno for his help with animal care. We give special thanks to Estephania Cortéz for technical support in the realization of this research project and Abel Santamaria for the water maze facilities. A.D., S.T., B.E., F.P.-S., S.M., M.R.O., and J.G. acknowledge the "Sistema Nacional de Investigadores" of Mexico for membership. Thanks to Thomas Edwards PhD., for editing the English language text.

**Conflicts of Interest:** Authors have no conflict of interest to declare. Also, all authors declare the availability of this manuscript.
