Reprint
Zika Virus and Host Interactions
Edited by
March 2021
256 pages
- ISBN978-3-03943-949-2 (Hardback)
- ISBN978-3-03943-950-8 (PDF)
This is a Reprint of the Special Issue Zika Virus and Host Interactions that was published in
Biology & Life Sciences
Medicine & Pharmacology
Summary
Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.
Format
- Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
Keywords
Zika virus; peroxisomes; innate immune response; interferon; astrocytes; fetal brain; zika virus; flaviviruses; T cells; host-pathogen interactions; zika virus; flavivirus; tight junctions; claudins; ZO-1; blood-placental barrier; placenta; Zika virus; apoptosis; viral replication; Bcl-2 protein family; Zika virus; ZIKV; virus host interactions; pathogenesis; MR766; guinea pig; subcutaneous; vaginal; sexual transmission; virus transmission; flavivirus; Zika virus; envelope protein; glycosylation; fusion loop; viral fusion; cell entry; flavivirus; Zika virus; NS5 protein; nuclear localization; inflammation; innate immunity; extracellular vesicles; Zika virus; cellular communication; C6/36 cells; human monocytes; endothelial vascular cells; ZIKV; protein–protein interaction; non-structural viral proteins; network; flavivirus; JAK/STAT; cytokine; West Nile virus; Zika virus; HSP90; NS5; virus–host interactions; anti-viral signaling; immune response; flavivirus; immune response; inflammatory mediator; Sertoli cells; Leydig cells; ZIKA virus; arboviruses; infertility; Zika virus; IFN; RIG-I; MDA5; apoptosis; NS5; IFNAR1; zika; host; interferon; cell death; placenta; NS5; peroxisome; mosquito; guinea pig; tight junction