*2.3. Bioactivity*

Litoralimycins A (**1**) and B (**2**) were evaluated for their minimum inhibitory concentration (MIC). Both compounds showed only a very weak activity against *Staphylococcus aureus* Newman and *Bacillus subtilis* DSM10<sup>T</sup> with MIC values of 66.7μg/mL, respectively. No further effects were detected against any Gram-negative bacteria or fungi. (Table S1). However, cytotoxic effects against different cell lines were detected for **1** (Table 2). Litoralimycin B (**2**) with its truncated side chain showed much weaker cytotoxic activity.


**Table 2.** Cytotoxic activities of litoralimycins A (**1**) and B (**2**) against different cell lines. Values indicate IC50 in μg/mL.
