*3.4. Water Solubility*

The water solubility was evaluated by the Shake Flask method [41]. Briefly, 6 mg of the compound was added to 6 μL of UPW and snSW in Eppendorf tubes. The tube was stirred at 24 ± 1 for 1 h and, after this time, GAP was completely solubilized in both waters. Solubility was defined according to USP [29].
