**Preface to "Flavonoids and Their Disease Prevention and Treatment Potential"**

During the last decade, interest in the use of dietary flavonoids to prevent human diseases and as pharmaceutical leads has been exponentially extended. Flavonoids, a sub-class of plant polyphenols, have exhibited numerous health-promoting physiological benefits in a wide range of investigations, from cell-based assays to randomized, controlled human clinical trials. This e-book consists of an editorial overview, four reviews, and fifteen original research articles published in the Special Issue of *Molecules* titled "Flavonoids and Their Disease Prevention and Treatment". Each of these papers contributes significantly to discovering and validating the beneficial physiological functions and therapeutic potential of dietary flavonoids. Beyond their role as plant food dietary antioxidants, new insights are presented for the potential use of flavonoids—and their derivatives—as effective therapeutics to manage many chronic and metabolic disorders, including certain cancers. Flavonoids also offer promising applications in the management of infectious diseases, including COVID-19.

> **H.P. Vasantha Rupasinghe** *Editor*
