**4. Conclusions**

Our in vitro data wanted to emphasize the effects of table grape polyphenolic compounds on some molecular mechanisms involved in tumorigenesis. Moreover, the lipidomic approach followed in this study provided valuable information for understanding the protective effect of two GSEs studied on human cell metabolism. Given their ability to influence cell morphology, the flavonoid and non-flavonoid compounds present in table grapes could become a promising dietary source for cancer prevention and treatment.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/1420-3049/25/15/3352/s1, Figure S1A: Positive extract ion chromatogram (EIC) of M<sup>+</sup> signals of the anthocyanins identified, Figure S1B: Negative extract ion chromatogram (EIC) of [M − H]<sup>−</sup> signals of the phenolic compounds identified, Table S1: Main MS/MS fragments and mean signal intensity of the metabolites identified in the samples.

**Author Contributions:** Conceptualization, V.T. and M.N.; methodology, V.T., I.G., R.A.M., V.D.N., R.F., M.D.R., M.P.S., N.D., and E.F.; data curation, V.T., I.G., R.A.M., R.F., and V.D.N.; writing—original draft preparation, V.T., I.G., R.A.M., R.F., and M.P.S.; writing—review and editing, V.T., M.G.C., and M.N.; supervision, M.N. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by RC 2020-2022, Linea 2, Prg. 15 (D.D.G. n. 2 – 10.01.2020) and "PO Puglia FESR 2007-2013, Asse I, Linea 1.2, (codice n. 47)".

**Conflicts of Interest:** The authors declare no conflict of interest.
