*3.8. Cytotoxicity Assays*

The cytotoxic activities were evaluated with the sulforhodamine B (SRB) assay [27], using five human tumor cell lines: A549, HCT116, MCF-7, Hela, and Hep G2. Adriamycin was used as a positive control.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/1660-3397/18/3/132/s1, Figure S1. *Aspergillus terreus* RA2905 and its phylogenetic tree of ITS gene, Figures S2−S39: the NMR, ESIMS and HRESIMS spectra, Figure S40: Key HMBC correlations of compound **3**, Figure S41: crystal diagram of compound **6**, Figure S42: key HMBC correlations of compounds **8** and **9**, Figure S43: the CD spectrum of compound **8**, Figure S44: the CD spectrum of compound **9**.

**Author Contributions:** Conceptualization, C.-Y.W. and H.-S.G.; Methodology, J.-S.W.; Data analysis, J.-S.W., X.-H.S., C.-L.S., and X.-L.Z.; Bioassays, J.-S.W., X.-H.S., and G.-S.Y.; Writing—Original draft preparation, J.-S.W. and X.-H.S.; Writing—Review and editing, J.-S.W., X.-M.F., and C.-Y.W. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao, China) (No. 2018SDKJ0406-5), the National Science and Technology Major Project for Significant New Drugs Development, China (No. 2018ZX09735-004), the Shandong Provincial Natural Science Foundation (Major Basic Research Projects) (No. ZR2019ZD18), the Program of Open Studio for Druggability Research of Marine Natural Products, the Pilot National Laboratory for Marine Science and Technology (Qingdao, China) directed by Kai-Xian Chen and Yue-Wei Guo, and the Taishan Scholars Program, China.

**Conflicts of Interest:** The authors declare no conflict of interest.
