Paget (1855–1926) [46]

The publics' perception of scientists versus anti-vivisectionists began shifting after the brown dog a ffair because a link between scientific growth and an improving quality and quantity of life was becoming apparent. Medical scientists, becoming sensitive to the public's concerns, were also making e fforts to dispel the accusations of cruelty being made against them whilst capitalising on the role of animal experimentation in understanding—if not treating—conditions such as diabetes. This was exemplified by the publication of Stephen Paget's *Experiments on Animals* in 1900. A tome of 381 pages, 24 were devoted to the chapter on "Anæsthetics Used For Animals"—a considerable improvement from Sanderson's aforementioned handbook in which advice on anaesthesia was notable by its absence. Please see Figure 3 for the dates of the publication of material contributing to the promotion of anaesthetics and analgesics in animal experiments.

**Figure 3.** Dates of the publication of material contributing to promotion of anaesthetics and analgesics in animal experiments. Alternatively shaded x axis blocks each represent a 50 year epoc. A(SP)A 1986: The Animals (Scientific Procedures) Act 1986. ARRIVE: Animals in Research: Reporting in Vivo Experiments; Reporting guidelines. Additional dates for reference: [1]: 1873 Sanderson publishes, "Handbook for the Physiological Laboratory"; [2]: the Magnan "a ffair"; [3]: the brown dog a ffair. AVA: Association of Veterinary Anaesthetists; VAA: Veterinary Anaesthesia and Analgesia. Grindley [47] Keele and Smith [48] and Chenoweth and Van Dyke [49] are di fficult to locate and on 12 September 2020, were unavailable online. Morton and Gri ffiths [50] is a landmark paper insofar that it was the first to emphasize an ethical and scientific imperative to use analgesics in laboratory animals.
