**5. Therapeutics**

As mentioned above, treatments for RT-induced hyposalivation are limited to sialagogues, such as pilocarpine and cevimeline, which induce saliva secretion from residual acinar cells, artificial saliva and the single FDA-approved radioprotective therapeutic, amifostine. There are also a number of salivary gland radiation sparing techniques that have been utilized to minimize IR-induced damage. Promising new radioprotective and regenerative approaches are being investigated in preclinical animal models. The next section summarizes current and promising therapeutic approaches to IR-induced salivary gland dysfunction.
