**Appendix A. Database Search Strategies**

Search (1) August 2017




#### Search 2: September 2017

After reviewing the returns from the original search in August 2017, we amended the search in September 2017 to identify studies on the health effects of substance use (for cannabis, alcohol, opioids, tobacco/nicotine). In addition, we added sex/gender terms and substance-specific terms. The search was amended as follows:

1. Health effects terms were added to the search terms.

("health effect" or "heath effects" or "effect on health" or "effects on health" or "affect \* health" or "affect \* the health" or "heath impact \*" or "impact \* on health" or "impact \* health"). ti,ab. [HEALTH EFFECTS]

These terms were searched in combination with the gender terms and substance terms as follows: Concept 1—Gender/sex

AND Concept 2—Substances (opioids, alcohol, tobacco, cannabis) AND Concept 3—health effects

