*Outcome:*

	- Changes in substance use (uptake/initiation, harms associated with use cessation, reduction)
	- Changes in client perceptions/attitudinal change
	- Changes in service provider perceptions
	- Changes in retention/treatment completion
	- Increased use of services
	- improved health and quality of life outcomes

Note: Studies that report on one or more of the four substances in relation to sex/gender *only* in the baseline characteristics of the sample will be excluded, even if statistical significance is reported.
