**Contents**



#### **About the Editors**

**Andrea Colantoni** is an Associate Professor in Agricultural Mechanics full time at Tuscia University. Deputy director of the Experimental Farm 'Nello Lupori' of Tuscia University. Member of the Italian Association of Agricultural Engineers which is part of the European Society of Agricultural Engineers (EurAgEng), of the International Commission of Agricultural Engineering (CIGR), of the Italian Association of Scientific Agricultural Societies (AISSA) for the 3rd edition on "Mechanization and technologies for agriculture" and for the 5th edition on "Ergonomics and work organization". Author of more than 200 publications in excellent journals with high impact factors.

**Massimo Cecchini** is an Associate Professor in Agricultural Mechanics full time at the University of Tuscia. He obtained his degree in Agricultural Sciences in 1993 with 110/110 cum laude. From 2012 to 2016, he was the coordinator of the PhD program in Agricultural and Forestry Systems Engineering at the University of Tuscia. Since 2016, he has been a member of the PhD course in Engineering for Energy and Environment of the University of Tuscia. Since 2001, he is has been a member of AIIA, the Italian Society of Agricultural Engineering, member of EurAgEng—European Society of Agricultural Engineers, of CIGR—International Commission of Agricultural Engineering, and AISSA—Italian Association of Agricultural Scientific Societies.

**Alvaro Marucci** is a Full Professor in rural buildings and agro-forest land planning. The main issues addressed in his research include the following:


**Fabio Recanatesi** is an Associate Professor in Land Use Planning and Geographic Information System (GIS) at the University of Tuscia (Italy). Professor Recanatesi is an expert in geomatics and remote sensing for the environmental risk assessment of natural and semi-natural environments and a scientific consultant at the Site of Community Importance (SCI) of the state nature reserve of Castelporziano (Rome).

**Elena Di Mattia** received her PhD degree in 1999 on "Energetics and Environmental Technologies to Development" at the University of Roma "La Sapienza" and, since 2002, has been a researcher (AGR/16) at DAFNE, in Tuscia University, working on Agro-Environmental Microbiology and Soil Microbiology. Her main research works focus on microbial ecology and physiology of soil and rhizosphere: microbial activities of inoculants and plant biostimulation. Moreover, she is involved in some studies concerning waste recycle valorization (i.e., biochar, wastewater, poly-caprolactone, and biodegradable polymer) using bacterial strains and microbial consortia also managed by nanotechnology.

**Rodolfo Picchio** obtained a Forest Science degree and a PhD degree in Forest Mechanizationfrom Tuscia University in Viterbo. From 2004 to 2014, he worked as a university researcher and, since 2014, has been an Associate Professor in Forest Logging and Wood Technologies. Since 2014, he has also led the 'Forest Utilization Work Group' at Tuscia University (DAFNE). From 2015 to 2017, he served as the president of the Master program of Forest Science "Conservation and Restoration of the Forest Environment and Soil Defense" at Tuscia University (DAFNE). He has served on the board of the PhD programs of "Science and Technologies for Forest and Environmental Management" (2005–2013) and "Engineering for Energy and Environment" (since 2018) at Tuscia University. His fields of expertise include forest logging, forest mechanization, precision forestry, wood technologies, and the environmental impacts of wood harvesting operations. He has worked as the Italian representative in two EU COST Actions on silviculture and biomass. Furthermore, he has co-authored 85 peer-reviewed papers in international journals indexed by WoS and Scopus, 25 technical books, and over 180 papers in technical magazines. He is also on the editorial boards of four international scientific journals covering forestry and forest engineering subjects. He is a member of the scientific Society of Silviculture and Forest Ecology.

**Mauro Villarini** is a mechanical engineer. He attained his PhD in Energy Systems from 2007 to 2012 and also served as a Research Assistant at Sapienza University. Since 2012, he has been an Assistant Professor at the DAFNE Department of Tuscia University of Viterbo teaching the following courses: Energy and Environment, Renewable Energies, Energy Systems, Fluid Dynamics, Management of Energy and Industrial Plants within the Master's Degree course of Mechanical Engineering (DEIM Department) and the course of Forest and Natural Sciences (DAFNE Department) of Tuscia University.

**Valerio Cristofori** is an Associate Professor in Horticulture at the Department of Agriculture and Forest Sciences—Tuscia University. His research skills are focused on the evaluation of qualitative traits in nuts and temperate fruit species. Other research activities treat the individuation, characterization, and conservation of local fruit germplasm, including minor fruit species of nutraceutical interest. He is also involved in the investigation of innovation in cultivar choice of nut species and orchard management. He is currently the Principal Investigator of the Local Unit in the European Project Horizon 2020 "Pantheon—Precision Farming of Hazelnut Orchards (Grant agreemen<sup>t</sup> n. 774571)". His research activity is manifested in more than 50 publications in international journals (indexed in Scopus), several book chapters, and in many other publications in national journals and proceedings of International Congresses.

#### **Preface to "WP3—Innovation in Agriculture and Forestry Sector for Energetic Sustainability"**

This Special Issue was founded after the creation of a department of excellence at the University of Tuscia (Viterbo, Italy). In particular, in the context of the WP3 objective, there is a need for innovation in the agricultural and forestry sectors for energy sustainability. Renewable energy sources and the rational use of energy represent an important agricultural and forestry resource in a local context against climate change. The first topic that this Special Issue will address is identifying the energy potential from agroforestry biomass, also dealing with the production of agricultural and forestry biomass in terms of supply and logistics; short rotation forestry (SRF); agricultural and forestry residues and their valorization; the main techniques of cultivation, the mechanization of biomass production, harvesting, and pre-treatment; the energy and environmental balance of biomass production; further forms of by-product valorization; evaluation of the potential of land use and planning tools. The second topic encompasses the performance analysis of prototypal systems for energy conversion, including hydrogen, power, and/or heat production plants and the pertinent thermodynamic cycles; sustainable renewable energy technologies (RETs); biomass thermochemical energy conversion technologies; system analysis and the integration of production and conversion and integrated bioenergy systems, including economic, environmental, and managemen<sup>t</sup> aspects. The third topic focuses on energy sustainability for environmental mitigation, such as the impact of large-scale/small-scale bioenergy systems.

**Andrea Colantoni, Massimo Cecchini, Alvaro Marucci, Fabio Recanatesi, Elena Di Mattia, Rodolfo Picchio, Mauro Villarini, Valerio Cristofori** *Editors*

#### **WP3—Innovation in Agriculture and Forestry Sector for Energetic Sustainability**

#### **Andrea Colantoni \*, Rodolfo Picchio \*, Alvaro Marucci, Elena Di Mattia, Valerio Cristofori, Fabio Recanatesi, Mauro Villarini, Danilo Monarca and Massimo Cecchini**

Department of Agricultural and Forestry Sciences (DAFNE), University of Tuscia, via S. Camillo De Lellis, 01100 Viterbo, Italy; marucci@unitus.it (A.M.); dimattia@unitus.it (E.D.M.); VALERIO75@UNITUS.IT (V.C.); fabio.rec@unitus.it (F.R.); mauro.villarini@unitus.it (M.V.); monarca@unitus.it (D.M.); cecchini@unitus.it (M.C.) **\***Correspondence:colantoni@unitus.it(A.C.);r.picchio@unitus.it(R.P.);Tel.:+39-0761357356(A.C.)

Received: 15 September 2020; Accepted: 22 October 2020; Published: 16 November 2020

#### **1. Documents in This Special Issue**

Papers submitted and published in this Special Issue "WP3—Innovation in Agriculture and Forestry Sector for Energetic Sustainability" bring together some of the latest research results in the field of biomass valorization and the process of energy production and climate change and other items about energetic sustainability [1–20]. Moreover it is very important to evaluate the safety aspects for energy plant use [21–24].

Responses to our call generated the following statistics:


Published submissions are related to 15 published articles.

We found the edition and selections of papers for this exercise very inspiring and rewarding. We also thank the editorial sta ff and reviewers for their e fforts and help during the process.

For better comprehension, the contributions to this special issue are split in parts, as follows.

#### *1.1. Research Articles*

The first contribution in this section explores the Performance Assessment of Front-Mounted Beet Topper Machine for Biomass Harvesting by Volodymyr Bulgakov, Simone Pascuzzi, Semjons Ivanovs, Francesco Santoro, Alexandros Sotirios Anifantis and Ievhen Ihnatiev. In this article, the authors focused their attention on the analysis of performance related to the operation of a new high-quality prototype of sugar beet top harvester that they built in Ukraine. Sugar beet is an extensive crop of of grea<sup>t</sup> agronomic value with significant productive and economic returns and Ukraine's sugar beet accounts for about 5.1% of the overall world production. Sugar beet and the by-products resulting from its manufacturing transformation are a significant renewable energy resource; a top sugar beet harvester, front-mounted on a tractor, was built by the authors in Ukraine. After the description of the beet topper machine features, the field tests, which took place in the Kiev region, were presented with reference to the tractor traction power using sensors able to measure torque and angular speeds. The experimental data were processed and showed that the energy costs related to the single work row of the prototype beet top harvesting machine were significantly lower than the corresponding performance parameter values of beet top-harvesting machines currently in use in Ukrainian farms.

The second paper is entitled Environmental and Economic Analysis of an Anaerobic Co-Digestion Power Plant Integrated with a Compost Plant and has been written by Sara Rajabi Hamedani, Mauro Villarini, Andrea Colantoni, Maurizio Carlini, Massimo Cecchini, Francesco Santoro and Antonio Pantaleo. The article presents an analysis of economic and environmental issues of anaerobic digestion power-generation plants considering the Italian market evolution and basedon the scenario of a real case study. The spread of anaerobic digestion power plants slowed down after the remarkable growth that occurred between 2009 and 2016. The specific analysis considers also the benefits of use of digestate as fertilizer and of cogeneration heat in order to exploit all the resources potentially coming from these systems. Furthermore, a life-cycle analysis (LCA) has been carried out and the unreleased environmental emissions were converted into economic benefits by means of a stepwise approach. The final results of the analysis showed that the integration of a compost plant within the biogas plant integrated in the Italian electricity grid regulation allowed it to reach good financial performance in terms of IRR (internal rate of return) and NPV (net present value).

The third article entitled "The techno-economic modelling of biomass pellet routes: feasibility in Italy" was written by Antonio Pantaleo, Mauro Villarini, Andrea Colantoni, Maurizio Carlini, Francesco Santoro and Sara Rajabi Hamedani. Wood and agricultural biomass pellets boost the potential of bio-fuels for power production in tertiary and residential sectors. The production of pellets, however, is a multi-stage process where the supply-processing phases and the overall energy input strongly depend on the characteristics of the input biomass. In this paper, a model to evaluate the economic issues of agro-pellet was developed. The breakdown structure of costs has been represented after having described the manufacturing process from raw biomass to finished pellet. CAPEX and OPEX have been determined by means of a mathematical model. In the CAPEX, pelletizing, drying, pretreatment storage plants in addition to installation and engineering costs have been considered. The annual operation and maintenance costs have been calculated considering the following expense items: raw biomass supply and transport, biomass drying, electricity consumption, plants maintenance and personnel. After the model implementation, the analysis was applied to the case study of an Italian firm producing doors and windows in laminated wood. The analysis was then carried out within 4 di fferent scenarios where the organization and, especially, the origin of the biomass used for the pellet production changes. The best scenario is the second one in which all the biomass treated comes from the production process of the company. Finally, the result showed that use of forestry residues with high moisture and high ash content, high costs of collection/transport, and high costs of pre-treatment and drying is not financially competitive.

The fourth papers entitled Evaluation of Compressor Heat Pump for Root Zone Heating as an Alternative Heating Source for Leafy Vegetable Cultivation has been written by Chiara Terrosi, Sonia Cacini, Gianluca Burchi, Maurizio Cutini, Massimo Brambilla, Carlo Bisaglia, Daniele Massa and Marco Fedrizzi. It aims to investigate the best value heating system for protected horticulture represented by leafy vegetable cultivation with a focus on the performance of the heat pump. It used 840 sweet basil seedlings during the experimental tests within the case study. The three systems examined were a condensing boiler, a heating pump and a air-to-air heater. The purpose was to verify the applicability considering the moderate temperature achieved by this system and the energy efficiency considering the absence of electricity, produced from renewable energy resources, to feed the heat pump itself. The heating distribution was described and the results presented showing that an optimization of the system can be achieved by reducing energy needs, using energy more e fficiently and using less expensive energy sources. In particular, the adoption of an electric heat pump for greenhouse heating allows remarkable energy savings to be obtained and, especially, with respect to the condensing boiler and the air heater, the energy reduction amounts to 45%.

The fifth article entitled Influence of Oxidant Agent on Syngas Composition: Gasification of Hazelnut Shells through an Updraft Reactor has been written by Francesco Gallucci, Ra ffaele Liberatore, Luca Sapegno, Edoardo Volponi, Paolo Venturini, Franco Rispoli, Enrico Paris, Monica Carnevale and Andrea Colantoni. This work concerns a laboratory test at Sapienza University of Rome of an updraft gasifier reactor fed with hazelnut shells, profitably used as fuel in thermo-chemical processes, such as direct combustion or gasification. The tests were aimed to study the e ffect of an oxidant agen<sup>t</sup> on syngas quality (namely its lower heating value), composition, producible energy, and cold gas efficiency. Then, temperature distribution, syngas composition and heating value, and producible energy were measured. The syngas flow produced by the two di fferent oxidant agent, air and steam, was roughly the same but its quality was considerably di fferent. This di fferent performance can be notice by the following results: syngas produced by steam gasification had a lower heating value of 13.1 MJ/Nm<sup>3</sup> with an energy flow of 5.4 MJ/s. On the contrary, the syngas produced by air gasification had a lower heating value of less than 6 MJ/Nm<sup>3</sup> with a 3.3 MJ/s energy flow.

The sixth article entitled Sustainability Assessment of Alternative Strip Clear Cutting Operations for Wood Chip Production in Renaturalization Management of Pine Stands was written by Janine Schweier, Boško Blagojevi´c, Rachele Venanzi, Francesco Latteriniand Rodolfo Picchio. The object of this paper is a sustainability impact assessment approach was applied to understand how to modify forest operation planning in order to minimize environmental impact.

The work highlights the urgen<sup>t</sup> exigence to apply silvicultural managemen<sup>t</sup> strategies in order to support vegetation dynamics and enhance stand ecology, like the renaturalization concept. The forest operations are essential with respect to the environmental issues of this topic and sustainable forest managemen<sup>t</sup> should be implemented. The objective of the forest operations presented by this work was that the forest wood chains could support the aforementioned strategy of renaturalization in typical a fforested pine plantations in the Mediterranean basin. Considering the plethora of factors and criteria, often conflicting, to be considered, a multi-criteria decision analysis was applied. Three di fferent forest wood chains were applied in pine plantations, all di ffering in the extraction system (animal, forestry-fitted farm tractor with winch, and double drum cable yarder). Twelve economic, environmental and socio-ecological indicators were selected and calculated in order to address the sustainability assessment. After that a multi-criteria decision analysis has been implemented. Results showed that first ranked alternative was case 2, in which extraction was conducted by a tractor with a winch. The main reason was that this alternative had best performance for 80% of the analyzed criteria.

The seventh paper is entitled Production of Wood Pellets from Poplar Trees Managed as Coppices with Di fferent Harvesting Cycles and was written by Vincenzo Civitarese, Andrea Acampora, Giulio Sperandio, Alberto Assirelli and Rodolfo Picchio. This article aims to study high-density biomass plantations and the particular case short rotation wood coppice of poplar has been focused on and, by means of the CREA farm, was exploited to develop the experimental activity using di fferent treatments with harvesting cycles of 3, 6 and 9 years. The objective of the study was to identify the best raw material suitable for pellet production from trees or stems. The crops were subdivided by crop cycle and type of product in six groups separately stored in six bins after having been chipped and refined. Then, dehydration and pelletization the moisture content was measured in three di fferent times. During the monitoring process, the crops were sized and the dehydration process controlled. The pelletizing process using high density poplar plantation as a raw material highlights the possibility of obtaining a product that meets many of the quality standards required on the market.

The eighth article is entitled Optimizing the 3D Distributed Climate inside Greenhouses Using Multi-Objective Optimization Algorithms and Computer Fluid Dynamics and was written by Kangji Li, Wenping Xue, Hanping Mao, Xu Chen, Hui Jiang and Gang Tan. This work focuses on greenhouses considered important for densely-populated regions. Then, the modelling of the micro-climate of greenhouses by means of a hybrid computational fluid dynamics -evolutionary algorithm was implemented. The objective was to determine the optimal combination of parameters in order to make the crops grow and corresponding to the Pareto frontier. To that aim, a commercial greenhouse located in China was used for the validation of the aforementioned model. Then, after the model construction, it was validated with a field experiment. The temperature was measured and compared with values determined by the model. Afterwards, the optimization process was based on the following two problems: first, how to find out multiple variables' optimal setting points according to multiple environmental requirements; and second, for local planting areas, how to adjust environmental

variables with high spatial resolution to find the balance of energy saving and environment suitability. Twenty five pairs of control variables from a total of 250 chromosomes were identified belonging to the optimum set point basis. This way, the optimal tradeo ff between energy e fficiency and environmental suitability was determined. A detailed analysis may be provided that helps find the potential of the crop yield and energy conservation.

Moreover, other articles published in this special issue are:

Oscillations Analysis of Front-Mounted Beet Topper Machine for Biomass Harvesting by Volodymyr Bulgakov, Simone Pascuzzi, Alexandros Sotirios Anifantis and Francesco Santoro. The goal of this study was to assess the opportunity to use beet leaves and tops for the production of renewable energy. In this regard, one of the main issues is related to harvesting operation and waste recovery. In particular, considering the mechanization applied and the natural soil roughness, the machines are a ffected by angular oscillations in a longitudinal–vertical plane that strongly a ffect the cutting uniformity. Using Lagrange II-type equations some simulations were performed to assess the design and kinematic parameters of a front-mounted beet topper. According to the main findings, in order to improve the e fficiency of this harvesting machine, soil preparation is first needed, while the influence of the sti ffness and damping parameters of the feeler wheels pneumatic tires is not so clear.

Life Cycle Assessment and Environmental Valuation of Biochar Production: Two Case Studies in Belgium by Sara Rajabi Hamedani, Tom Kuppens, Robert Malina, Enrico Bocci, Andrea Colantoni and Mauro Villarini. This paper aimed to understand the economic feasibility of biochar production. Currently, the biochar production process may not be considered very cheap, hence it is di fficult to find lenders and business owners. In this initial phase, other aspects need to be carefully assessed, mainly related to two of the sustainability pillars, social and environmental. These issues were assessed through life-cycle analysis (LCA) performed for two potential biochar production systems and two di fferent feedstocks: willow and pig manure. The functional unit was one ton of biochar and the LCA database was SimaPro. The findings showed that the biochar production from willow achieves better results for all environmental impact categories surveyed in comparison to biochar from pig manure. Also, a monetary valuation was applied in order to weigh environmental benefits against environmental costs using the Ecotax, Ecovalue, and Stepwise approach. The final remarks highlight once again that willow biochar is preferable to biochar production from pig manure from the environmental point of view.

The last two research articles are:

Wood Chip Drying through the use of aMobile Rotary Dryer by Angelo Del Giudice, Andrea Acampora, Enrico Santangelo, Luigi Pari, Simone Bergonzoli, Ettore Guerriero, Francesco Petracchini, Marco Torre, Valerio Paolini and Francesco Gallucci. One of the main problems related to biomass use for energy production is the moisture content. Generally, moisture content negatively a ffects the energy conversion efficiency and the feedstock storage. For a number of issues, biomass drying is a crucial operation in which technology has tried in various ways to solve the most critical aspects. Currently, rotary dryers seem to be the best solution, concerning low cost of maintenance and consume of 15% and 30% less in terms of specific energy. This paper focused on the use of a new prototype of mobile rotary dryer concurrent flow on wood chips and three wooden biomass typologies have been assessed (*Populus* spp., *Robiniapseudoacacia* L. and *Vitis vinifera* L.). The drying process was a ffected by the initial moisture content: poplar in 8 h from 50% reached 41%; black locust in 6 h from 30% reached 21%; grapevine in 6 h from 30% reached 21%. Moreover, this study showed that other biomass characteristics (particle size distribution and bulk density) have an influence on drying operation and as a consequence on the process energy consumption. Findings showed that the three-biomass needed 1.61 (poplar), 0.86 (grapevine), and 1.12 MJ kg dry solids−<sup>1</sup> (black locust), with an e fficiency of thermal drying (η) respectively of 37%, 12%, and 27%. From this work some suggestions were formulated in order to improve the sustainability of the process: the need to increase the e fficiency of the thermal insulation of mobile dryer; the application of the mobile dryer in small-farms, and using exhaust gases from thermal power plants.

The final article is entitled: Sensitivity Analysis of Di fferent Parameters on the Performance of a CHP Internal Combustion Engine System Fed by a Biomass Waste Gasifier by Mauro Villarini, Vera Marcantonio, Andrea Colantoni and Enrico Bocci. This paper presented a study on the energetic valorization of residues from biomasses production. The energy production or proper conversion was undertaken through gasification and then by using an internal combustion engine with a generator. Sampling was undertaken selecting the most representative types of biomass waste from agricultural productions, and the most suitable one to be used in the gasification process. Generally, good quality syngas with up to 16.1% CO–4.3% CH4–23.1% H2 can be produced. The syngas's lower heating value may vary from 1.86 MJ/Nm<sup>3</sup> to 4.5 MJ/Nm<sup>3</sup> in the gasification with air and from 5.2 MJ/Nm<sup>3</sup> to 7.5 MJ/Nm<sup>3</sup> in the gasification with steam. The cold gas e fficiency may vary from 16% to 41% in the gasification with air and from 37% to 60% in the gasification with steam. A sensitivity analysis was used considering the cold gas e fficiency and the LHV, in order to select the best configuration process for the best quality syngas. The syngas quality was also assessed through the electrical e fficiency and the cogeneration e fficiency.

#### *1.2. Review Articles*

In addition to the original articles, two reviews were published in this special issue. Briefly, the first review treats Pellet Production from Woody and Non-Woody Feedstocks: A Review on Biomass Quality Evaluation by Rodolfo Picchio, Francesco Latterini, Rachele Venanzi, Walter Stefanoni, Alessandro Suardi, Damiano Tocci and Luigi Pari.

Forest and agricultural biomasses represent a notable fuel source and they are renewable and sustainable feedstock for energy production. Nowadays, many factors (economic, social and environmental) have greatly contributed to the increase of their consumption. Among these, pellet has a substantial importance with an increase in production and innovations, concerning both woody and non-woody biomass. This form of densified biomass can be composed of a broad spectrum of possible raw materials, and for this reason the assessment of its quality may be considered an important issue.

In this regard, worldwide research in the last decade produced a consistent number of scientific papers, and this review work is aimed to highlight the most interesting ones and to give the readers an overall view of the most current knowledge about this large and interesting topic. The authors focused on pellets from agricultural and forestry origin with a selection of papers from the last five years (2016–2020) and grouped them in four main topics: influence of di fferent agro-forest managemen<sup>t</sup> systems on pellet quality; analysis of pellets from pure feedstocks; influence of blending and binders on pellet quality; influence of pre- and post- treatments. A critical discussion on research that is missing, on future developments, and trends closed this work.

The other review is Revolutionizing towards Sustainable Agricultural Systems: The Role of Energy by Ilaria Zambon, Massimo Cecchini, Enrico Maria Mosconi and Andrea Colantoni. The purpose of this work was to increase the performances of primary sector focusing on bioeconomy and sustainability. The application of innovations is a progressive and integrated process. Knowing the governance and opening a dialogue with stakeholders is a fundamental step for innovation and development at national or international scale. However, when opposing normative guidelines for alternative systems of agriculture that arise, modernizations in agricultural and forestry may contribute to outlining more sustainable systems. Currently the primary sector, except for industrial agriculture, does not seem to develop adequately in terms of innovation. This work highlights the main innovations of recent years in the primary sector, including agriculture and forestry. In this sector, one of the main aids for pursuing adequate sustainable development is undoubtedly represented by energy. In this emerging framework, adequate technologies for concrete energy e fficiency are needed. Moreover, energy sustainability itself is one of the most discussed issues currently. With this review we try to understand which innovations have actually been received by the primary sector, highlighting their limits and opportunities.

#### **2. Conclusions**

In summary, the papers of the special issue represent some of the latest and most promising research results in this new and exciting field, which continues to make significant impact on real-world applications. We are confident that this special issue will stimulate further research in this area.

We thank all the authors for their contributions to this special issue.

**Author Contributions:** Conceptualization, A.C., M.C., D.M., A.M., R.P.; methodology, V.C., F.R., E.D.M., M.C., D.M., A.M., R.P., A.C.; data curation, M.V., A.C., V.C., R.P.; supervision, A.C. All authors have read and agreed to the published version of the manuscript.

**Funding:** Ministry for Education, University and Research (MIUR) according to the Italian Law 232/2016.

**Acknowledgments:** The special issue was partially supported by the Italian Ministry for Education, University and Research (MIUR) according to the Italian Law 232/2016 within the fund for the financing of universities "Departments of Excellence".

**Conflicts of Interest:** The authors declare no conflict of interest.
