*2.2. Analysis*

We tested whether HHT genotype (*ACVRL1*, *ENG*, *SMAD4*) was associated with clinical features including the presence of epistaxis, typical mucocutaneous telangiectasia, anemia, pulmonary AVMs, brain VMs, GI bleeding, and symptomatic liver VMs. For the purposes of our analysis, patients with micro-pulmonary AVMs were considered to be negative for pulmonary AVMs. All brain VM subtypes met the criteria for the brain VM phenotype. A combined phenotype was defined as the presence of both pulmonary AVM(s) and brain VM(s). Statistical analysis was conducted using the SPSS version 21.0.0. All *p*-values calculated were two-sided and significance was defined at *p* < 0.05. The Kruskal–Wallis test was used to compare the association between continuous variables (age) and genotype. To determine the association between clinical features and genotype (*ACVRL1*, *ENG*, *SMAD4*), a chi-square test was used.
