**5. Conclusions**

In conclusion, age, *ENG* mutation, tobacco use, and hemoglobin levels have been associated with GI involvement in HHT patients. Telangiectasia was more frequently found in the stomach and duodenum. Patients with large telangiectases have severe anemia and high RBC transfusion requirements. VCE should be considered in patients with a high suspicion of GI bleeding, even if EGD resulted negative. Among HHT patients, those with GI involvement need medical attention more often, with no di fferences in mortality.

**Author Contributions:** Conceptualization: J.M.M.-L. and A.R.-M.; data curation: J.M.M.-L., A.I., A.B., P.C. and A.R.-M.; formal analysis: J.M.M.-L., A.I., P.C. and A.R.-M.; investigation: J.M.M.-L., A.I., E.A., M. Á.S.-C., A.B., P.C., F.C., J.R., J.C. and A.R.-M.; methodology: J.M.M.-L. and A.R.-M.; supervision: J.R., J.C. and A.R.-M.; validation: J.M.M.-L., A.I., E.A., M. Á.S.-C., A.B., P.C., F.C., J.R., J.C. and A.R.-M.; visualization: J.M.M.-L., E.A., F.C. and A.R.-M.; writing—original draft preparation: J.M.M.-L., A.I., E.A., M. Á.S.-C., A.B., P.C., F.C. and A.R.-M.; writing—review and editing: J.M.M.-L., J.R., J.C. and A.R.-M; funding acquisition: A.R.-M. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the Instituto de Salud Carlos III, gran<sup>t</sup> number PI17/00669, co-funded by the European Regional Development Fund (ERDF), "A Way to Build Europe".

**Conflicts of Interest:** The authors declare no conflict of interest.
