*2.6. Regions of Interest (ROI)*

During resective surgery, the locations of biopsies on the patient's MRI were identified using a Medtronic StealthStation S8 Surgical Navigation system (Medtronic, Minneapolis, MN, USA) and application software (Version 1.1.0-39). The biopsy locations were recorded via screenshots. With this information, voxel locations were manually identified on our analytical setup and transformed into MNI-space by applying the patient's transformation affine. A one-half cubic centimeter sphere was used as a facsimile for the biopsy in MR image space.
