*4.7. Gene Expression Profiling*

Total RNA was isolated from skin substitutes using the RNeasy Mini Kit (QIAGEN, Toronto, ON, Canada) and its quality determined (2100 Bioanalyzer, Agilent Technologies, Mississauga, ON, Canada) as described [54]. Labeling of Cyanine 3-CTP-labeled targets, their hybridization on a G4851A SurePrint G3 Human GE 8 × 60K array slide (Agilent Technologies, Santa-Clara, CA, USA), and data acquisition and analyses were all performed as previously reported [54].

**Supplementary Materials:** Supplementary Materials can be found at http://www.mdpi.com/1422-0067/21/15/ 5215/s1.

**Author Contributions:** Conceptualization, M.S., S.M., R.S. and R.P.; methodology, M.S., S.M., G.R. and R.P.; software, M.S.; validation, M.S., S.M., G.R., R.S. and R.P.; formal analysis, M.S., S.M., G.R. and R.P.; investigation, M.S., S.M., G.R., R.S. and R.P.; resources, R.P.; data curation, M.S., S.M., G.R. and R.P.; writing—original draft preparation, M.S., S.M., G.R. and R.P.; writing—review and editing, M.S., S.M., G.R., R.S., E.L., and R.P.; visualization, M.S., S.M., G.R., R.S. and R.P.; supervision, E.L. and R.P.; project administration, R.P.; funding acquisition, R.P. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the Canadian Institutes of Health Research (CIHR), gran<sup>t</sup> number MOP-311262.

**Acknowledgments:** Authors would like to acknowledge the support provided by Israel Martel in cell culture. We thank Jacques Soucy for kindly providing psoriatic biopsies for the in vitro study on psoriatic cells. Mélissa Simard received studentships from the Fonds de recherche Québec-Santé (FRQS) and from the Fonds d'Enseignement et de Recherche (FER) of the Faculté de Pharmacie of Université Laval. Sophie Morin received studentships from the FER, from the Fondation du CHU de Québec—Université Laval and from the FRQS. Geneviève Rioux received studentships from the FER and the Centre de recherche en organogénèse experimentale de l'Université Laval/LOEX. Rachelle Séguin received studentships from the FRQS, the FER and from the Centre de recherche en organogénèse experimentale de l'Université Laval/LOEX. Roxane Pouliot is a career award scholar from FRQS. We would also like to acknowledge the Réseau de thérapie cellulaire, tissulaire et génique du Québec-ThéCell (a thematic network supported by the FRQS).

**Conflicts of Interest:** The authors declare no conflict of interest.
