**5. Conclusions**

The present study evaluated GM and TA activation in PD patients, proposing a comprehensive step-to-step analysis procedure based on a statistical approach from the detection of activation patterns from long gait sequences acquired in ecological conditions, integrated with verification of gait symmetry and coactivation analysis. The analysis allowed to identify different muscle activation patterns and their relative occurrence frequency, as well as coactivation schemes, in PD subjects, providing novel insight with respect to literature, where unique average patterns were identified, providing at times conflicting results. The improved methodology, here applied as an example to GM and TA in 20 PD subjects, is meant to be considered as a general procedure to be applied for the analysis of muscle activation patterns in pathologic subjects.

**Author Contributions:** Data curation, G.P.P., M.F.; Formal analysis, S.F. and R.S.; Methodology, G.P.P., S.F., R.S.; Project administration, D.F., G.F., S.F., R.S.; Software, G.P.P.; Supervision, S.F., R.S.; Writing—original draft, G.P.P.; Writing—review and editing, G.P.P., M.C.B., S.F., R.S. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Conflicts of Interest:** The authors declare no conflict of interest.
