**6. LUBAC Inhibitors**

LUBAC is the sole E3 that can generate a linear ubiquitin chain to regulate acquired and innate immune responses. Therefore, LUBAC inhibitors will facilitate investigations of its enzymatic mechanisms and the cellular bases for immune responses, and serve as potential therapeutics for various LUBAC-related disorders. As described above, stapled peptides targeting the HOIP-HOIL-1L interface suppressed the viability of ABC-DLBCL cells [138]. In this chapter, we summarize the recent advances in the development of small-molecule chemical inhibitors of LUBAC.
