*4.1. Materials*

Cysteamine, Tris(2-carboxyethyl)phosphine, 5,5--Dithiobis(2-nitrobenzoic acid), Thioflavin T, Heparin (H3393), dithiothreitol (DTT), acetonitrile, and Trifluoroacetic acid (TFA) were purchased from Sigma Aldrich (St Louis, MO, USA); Tubulin (T240) was purchased from Cytoskeleton (Denver, CO, USA), italian distributor Società italiana chimici (Rome, IT).
