*4.4. Anticancer Properties*

There have been reports of the effect of mineralization of collagen fibrils in bone tissue on the adhesion of cancer cells [84–86]. These studies are looking for the cause of bone metastases. One approach was to investigate the effect of extracellular matrix bone on metastasis. A study by Siyoung Choi et al. [87] demonstrated that the physiological mineralization of collagen fibrils reduces tumor cell adhesion with potential functional consequences for skeletal colonization of disseminated cancer cells in the early stages of breast cancer metastasis. Too little of the mineral part of the matrix may be associated with an increased risk of bone metastases. The study compared collagen-mineralized fibers and non-mineralized collagen for regulating the adhesion of metastatic breast cancer cells. Endothelial collagen mineralization can change the response of cancer cells first through integrin-mediated mechanotransduction.
