**5. Conclusions**

The recruitment and homing of MSCs are essential for bone healing. MSC mobilization accelerates bone healing mainly by stimulating angiogenesis and coordinating bone remodeling. FBP presented as a highly effective scaffold for applications in bone lesions because it accelerated tissue regeneration. We have concluded that the use of fibrin scaffold for mesenchymal stem cells pre differentiated in bone lineage have accelerated the bone healing process by keep cells viable on injury site without any adverse events.

**Author Contributions:** Conceptualization, C.F.Z.C. and R.S.F.J.; methodology, C.F.Z.C.; P.R.O.; and R.S.F.J.; software, L.A.J.; validation, C.F.Z.C.; F.C.L.-A.; L.A.J.; M.d.A.G. and R.S.F.J.; formal analysis, B.B.; investigation, C.F.Z.C. and P.R.O.; resources, F.C.L.-A.; L.A.J.; B.B. and R.S.F.J.; data curation, L.A.J. and M.d.A.G.; writing—original draft preparation, C.F.Z.C. and R.S.F.J.; writing—review and editing, C.F.Z.C.; P.R.O.; F.C.L.-A.; L.A.J.; M.d.A.G.; B.B. and R.S.F.J.; visualization, C.F.Z.C.; P.R.O.; F.C.L.-A.; L.A.J.; M.d.A.G.; B.B. and R.S.F.J.; supervision, R.S.F.J.; project administration, R.S.F.J.; funding acquisition, B.B. and R.S.F.J. All authors have read and agreed to the published version of the manuscript.

**Funding:** This study was supported in part by grants from the CAPES (Coordination for the Improvement of higher Education Personnel) [AUX-PE Toxinology Proc. No. 23,038.000823/201121]. R.S.F.J. is a CNPq PQ1C fellow researcher [303224/20185]. C.F.Z.C. was a FAPESP fellow researcher [FAPESP 2013/02004-3].

**Acknowledgments:** Special thanks to the center for the Study of venoms and venomous animals, CEVAP at São Paulo State University, UNESP, Brazil; and São Paulo State Research Support Foundation, FAPESP.

**Conflicts of Interest:** R.S.F.J. is a CNPq PQ1C fellow researcher [303224/20185]. C.F.Z.C. was a FAPESP fellow researcher [FAPESP 2013/02004-3]. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results". The other authors have no conflicts of interest to disclose in relation to this article.
