**2. Bioactive Compounds**

*Dendrobium* orchids possess a number of bioactive compounds that have been used as traditional Chinese medicine for thousands of years. In recent years, a number of *Dendrobium* transcriptomes have been announced, and it opens a way to predict gene functions via in silico analysis. Zhang et al. performed a comparative analysis of *PLP\_deC* genes in *D. o*ffi*cinale*, and the results showed that they may be involved in the responses of abiotic stress and consequently affect the biosynthesis of secondary metabolites [4]. Yuan et al. used weighted gene co-expression network analysis to predict crucial gene modules that may be involved in the regulation and biosynthesis of active compounds in *Dendrobium* orchids [5].

*Bletilla striata* (Thunb.) Reichb.f is an important traditional Chinese herb with multi-bioactivities. A dihydrophenanthrene compound, coelonin, was isolated and identified by Jiang et al. [6]. This compound mainly has anti-inflammatory activity, and the negative regulator phosphatase and tensin homologue on chromosome ten (PTEN) may play a crucial role in inhibiting macrophage proliferation and inflammatory factor secretion when treated silicosis.
