**4. Conclusions**


**Author Contributions:** H.W. (HaijianWang) and D.J. conceived and designed the experiments; H.W. (HaijianWang) and H.W. (Haiwei Wang) performed the experiments; H.W. (Haijian Wang) and D.J. analyzed the data; and H.W. (Haijian Wang) wrote the paper.

**Funding:** This research received no external funding.

**Acknowledgments:** This research receives support from the High-Tech Research Center and Nano-technology Project at Saitama Institute of Technology. All animal experimental protocols were conducted in compliance with the Guiding Principles for the Care and Use of Animals in the Field of Physiological Sciences approved by the council of the Physiological Society of Japan, and were permitted by the Animal Institutional Review Board of Saitama Institute of Technology in accordance with the guidelines of the U.S. National Institutes of Health.

**Conflicts of Interest:** The authors declare no conflict of interest.
