*2.1. Method, Software, and Flowchart*

This study leverages Monte Carlo simulation [39] in R Statistical Software [40] and an R Shiny web application [41]. The simulation follows the flowchart in Figure 1. Each step A through S is now discussed in different sections. Feasible ranges of user-based, simulation parameters along with their default values are shown in Table 1, while variable distributions are discussed in subsequent sections.

**Figure 1.** Simulation flowchart.


**Table 1.** Parameter Options in the Simulation.
