*4.5. Statistical Analyses*

All analyses and plots generated and analyzed using JMP 14 (SAS Institute Inc., Cary, NC, USA). For all analyses, *p*-values < 0.05 were considered significant.

**Author Contributions:** Conceptualization, D.G., T.D. and G.A.; methodology, D.G. and G.A.; sample collection, D.G., E.R. (Elina Rivkin), A.F., V.H., E.R. (Elad Rubin), D.K., I.S., T.D.; software, D.G. and G.A.; validation, D.G., E.R. (Elina Rivkin), A.F., L.S., V.H., E.R. (Elad Rubin), D.K., I.S., T.D., G.A.; formal analysis, D.G. and G.A.; investigation, D.G., E.R. (Elina Rivkin), A.F., L.S., V.H., E.R. (Elad Rubin), D.K., I.S., T.D., G.A.; resources, D.G., E.R. (Elina Rivkin), A.F., L.S., V.H., E.R. (Elad Rubin), D.K., I.S., T.D., G.A.; data curation, D.G., E.R. (Elina Rivkin), A.F., L.S., V.H., E.R. (Elad Rubin), D.K., I.S., T.D., G.A.; writing—original draft preparation, D.G.; writing—review and editing, T.D. and G.A.; visualization, T.D. and G.A.; supervision, G.A.; project administration, G.A.; funding acquisition, T.D. and G.A. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the Israel Science Foundation (ISF), grant number 193/16.

**Acknowledgments:** We would like to thank Ake T. Lu and Steve Horvath for their dedicated efforts with the DNAmAge online tool troubleshooting. We would also like to thank all the IMECS participants for their time and donation to our study.

**Conflicts of Interest:** The authors declare no conflict of interest.
