*2.3. Synthesis and Samples Preparation*

Racemic and enantiopure 3-(3,4-dimethylphenoxy)propane-1,2-diols, *rac*-**1** and (*R*)- or (*S*)-**1**, used as seed, were prepared from *rac*- and (*R*)- or (*S*)-3-chloropropane-1,2-diol by analogy with published procedure [21]. The crude diols were purified by recrystallization from hexane/EtOAc (3:1). Yield 67%–69%. Characteristics of the obtained diols are shown below:

*rac-*3-(3,4-Dimethylphenoxy)propane-1,2-diol, *rac*-**1**: mp 75–78 ◦C. (Lit. [31] mp 75–77 ◦C). (*R*)-3-(3,4-Dimethylphenoxy)propane-1,2-diol, (*R*)-**1**: mp 96–98 ◦C, [α]D<sup>20</sup> –7.7 (c 1.0, EtOH), 99.9% *ee* (chiral HPLC analysis, tR 7.7 min). [Lit. [31] mp 96–98 ◦C, [α]D<sup>20</sup> –7.7 (c 1.0, EtOH), 99.7% *ee*]. (*S*)-3-(3,4-Dimethylphenoxy)propane-1,2-diol, (*S*)-**1**: mp 96–97 ◦C, [α]D<sup>20</sup> +7.3 (c 1.0, EtOH), 99.2% *ee* (chiral HPLC analysis, tR 10.7 min). [Lit. [31] mp 96–97.5 ◦C, [α]D<sup>20</sup> +6.7 (c 1.0, EtOH), 99.5% *ee*].
