**Erik Temmel 1,2, Jonathan Gänsch 1,\*, Andreas Seidel-Morgenstern 1,3 and Heike Lorenz <sup>1</sup>**


Received: 27 April 2020; Accepted: 11 May 2020; Published: 14 May 2020

**Abstract:** A recently developed continuous enantioseparation process utilizing two coupled fluidized bed crystallizers is systematically investigated to identify essential correlations between different operation parameters and the corresponding process performance on the example of asparagine monohydrate. Based on liquid phase composition and product crystal size distribution data, it is proven that steady state operation is achieved reproducibly in a relatively short time. The process outputs at steady state are compared for different feed flow rates, supersaturations, and crystallization temperatures. It is shown that purities >97% are achieved with productivities up to 40 g/L/h. The size distribution, which depends almost exclusively on the liquid flow rate, can be easily adjusted between 260 and 330 μm (mean size) with an almost constant standard deviation of ±55 μm.

**Keywords:** fluidized bed; continuous; preferential crystallization; chiral separation; racemate resolution; enantiomer; asparagine monohydrate
