**4. Conclusions**

PGSS® is an advantageous processing technique that allows for the manufacturing of molten substances into solid microparticles, with a special interest for the processing of thermolabile compounds. Melting point measurements of GMS were essential to preliminarily determine the feasible PGSS® operating pressure and temperature conditions. The melting point depletion of GMS lipid under compressed CO2 of up to 9 ◦C is especially relevant from the energy savings and process economics points of view. SLMPs were thus obtained at operating temperatures (57 ◦C) well below the normal melting point of GMS (61 ◦C). Artificial intelligence tools combining artificial neural networks and fuzzy logic was as a successful analytical duo to model the production of SLMPs by the PGSS® process. The obtained models served to simplify the understanding of the SLMPs processing through linguistic rules. The model unveiled that the processing pressure and temperature, as well as the nozzle diameter, had a certain influence on the particle size distribution of the SLMPs and yield of particle production. These operating conditions influenced remarkably the mean diameter of the particles, with smaller particles obtained at high temperatures and pressures and small nozzle diameter.

**Author Contributions:** Conceptualization, C.L.-I. and C.A.G.-G.; methodology, C.L.-I. and E.R.L.; software, M.L.; investigation, C.L.-I.; data curation, M.L; writing—original draft preparation, C.L.-I.; writing—review and editing, E.R.L., J.F., M.L. and C.A.G.-G.; supervision, C.A.G.-G.; funding acquisition, J.F., M.L. and C.A.G.-G. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by Xunta de Galicia [ED431F 2016/010, ED431C 2020/17 & GRC ED431C 2020/10], MCIUN [RTI2018-094131-A-I00], Agrupación Estratégica de Materiales [AeMAT- BIOMEDCO2, ED431E 2018/08], Agencia Estatal de Investigación [AEI] and FEDER funds. C.A.G.-G. acknowledges to MINECO for a Ramón y Cajal Fellowship [RYC2014-15239]. Work carried out in the frame of the COST Action CA18224 (GREENERING) and funded by the European Commission.

**Conflicts of Interest:** The authors declare no conflict of interest.
