**4. Conclusions**

The current status of biomimetic scaffold systems based on polysaccharides has been reviewed regarding multi-stimulation, mechanical, electrical, and biochemical, in order to trigger specific responses in cells during growth and differentiation, specifically in the biomedical field. Some details of their production and properties have been summarized, including modification with conductive polymers and strategies for controlled drug release from porous materials, such as aerogels. Therefore, future studies of modified polysaccharide-based aerogels for tissue engineering could consider promoting physical, mechanical, electrical, and biochemical multi-stimulation with the aim to mimic in vivo conditions.

**Author Contributions:** Conceptualization, F.A.-H. and K.R.-S.; methodology, F.A.-H. and K.R.-S.; validation, F.A.-H., K.R.-S. and R.S.-P.; formal analysis, F.A.-H., K.R.-S. and R.S.-P.; investigation, F.A.-H., K.R.-S. and R.S.-P.; resources, R.S.-P.; data curation, F.A.-H., K.R.-S. and R.S.-P.; writing, original draft preparation, F.A.-H. and K.R.-S.; writing, review and editing, F.A.-H., K.R.-S. and R.S.-P.; visualization, F.A.-H., K.R.-S. and R.S.-P.; supervision, R.S.-P.; project administration R.S.-P.; funding acquisition, R.S.-P. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by Vicerrectoría de Investigación from Instituto Tecnológico de Costa Rica (VIE-ITCR), gran<sup>t</sup> number 5402-1360-4401 and the Ministerio de Ciencia, Tecnología y Telecomunicaciones de Costa Rica (MICITT), gran<sup>t</sup> number FI-038B-19.

**Acknowledgments:** The authors would like to thank the Centro de Investigación y Extensión en Materiales (CIEMTEC) and the Centro de Investigación en Biotecnología (CIB) from Instituto Tecnológico de Costa Rica. Aerogels COST action (CA18125). F.A.-H would like to thank Carlos A. García-González for his mentoring on aerogel processing and characterization.

**Conflicts of Interest:** The authors declare no conflict of interest.
