**5. Patents**

RU Patent #2394910 Luminescent biocatalyst for the determination of toxicants.

RU Patent #2255975 Recombinant plasmid DNA pTES-His-OPH and producer of oligo-histidine containing organophosphate hydrolase.

**Author Contributions:** Conceptualization, E.E.; methodology, E.E., A.I.; validation, O.M. and N.S.; formal analysis, O.M.; investigation, O.M. and N.S.; data curation, N.S.; writing—original draft preparation, O.M. and N.S.; writing—review and editing, E.E.; visualization, O.M. and N.S.; supervision, E.E.; project administration, E.E.; funding acquisition, E.E. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was financially supported by Russian Science Foundation (grant 16-14-00061).

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** The data presented in this study are available in this article.

**Acknowledgments:** This research was performed according to the Development program of the Interdisciplinary Scientific and Educational School of Lomonosov Moscow State University "The future of the planet and global environmental change". The authors thank Ilya Lyagin (Chemistry Faculty, Lomonosov MSU, Moscow, Russia) for his valuable comments on calibration plots obtained with cholinesterases.

**Conflicts of Interest:** The authors declare no conflict of interest E.E. and A.I. are co-inventors and patent holders of the RU patent #2394910; E.E. is inventor of RU patent #2255975 which involves producer of His6-OPH and the plasmid with gene encoding synthesis of the enzyme as a base active compound.
