3.3.2. IGFBP-3

As an effect of age in all female mice, a substantial increase of IGFBP-3 (Figure 4) in serum was observed between 2 and 16 weeks of age (*p* < 0.001). In addition, a reduction was observed in all female mice between week 16 and week 54 (*p* < 0.001). Similarly in all male mice, an increase of IGFBP-3 in serum between weeks 2 and 11 (*p* < 0.001) and a decrease between weeks 11 and 54 (*p* < 0.001) was observed. Significant effects of age are presented for separate mouse lines in Figures 3 and 4 (interactions of age, gender, and mouse line).
