Initial conditions

The initial conditions are the following:

$$\begin{array}{llll} atp=2.0 & nad=0.6 & glu=5.0\\ fru=5.0 & triop=0.6 & tp=0.7\\ pyr=8.0 & ac=0.08 & ace=0.02 \end{array}$$

Real parameter values

> The real values of the parameters are the following [36]:


where we indicate the set of possible values of the parameters in the square brackets.

We note that for the sake of our experiments, we set *k*0 to 0 (originally: *k*0 = 50 [36]) in order to forbid a constant injection of *glu*, and *k*9 to 0 (originally: *k*9 = 80 [36]) in order to avoid oscillatory behavior of the system.

## **3. Experimental Setup**

The experiments have been carried *in silico* in which the performance of the selected algorithms has been evaluated.
