*Article* **New Benthic Cyanobacteria from Guadeloupe Mangroves as Producers of Antimicrobials**

### **Sébastien Duperron 1,2,\*, Mehdi A. Beniddir 3, Sylvain Durand 1, Arlette Longeon 1, Charlotte Duval 1, Olivier Gros 4, Cécile Bernard 1 and Marie-Lise Bourguet-Kondracki 1,\***


3 Équipe "Pharmacognosie-Chimie des Substances Naturelles" BioCIS, CNRS, Université Paris-Saclay 5 rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France; mehdi.beniddir@u-psud.fr


Received: 27 November 2019; Accepted: 19 December 2019; Published: 23 December 2019

**Abstract:** Benthic cyanobacteria strains from Guadeloupe have been investigated for the first time by combining phylogenetic, chemical and biological studies in order to better understand the taxonomic and chemical diversity as well as the biological activities of these cyanobacteria through the effect of their specialized metabolites. Therefore, in addition to the construction of the phylogenetic tree, indicating the presence of 12 potentially new species, an LC-MS/MS data analysis workflow was applied to provide an overview on chemical diversity of 20 cyanobacterial extracts, which was linked to antimicrobial activities evaluation against human pathogenic and ichtyopathogenic environmental strains.

**Keywords:** benthic cyanobacteria; tropical mangrove; Guadeloupe; phylogenetic diversity; chemical diversity; molecular networking; antimicrobial activity
