*3.1. Species and Databases*

Twenty-three species of *Tremellomycetes* were used in the study (Table 2). Different databases, such as NCBI (https://www.ncbi.nlm.nih.gov/), FungiDB [52] and Joint Genome Institute MycoCosm portal [8], were browsed for cryptococcal species genomes. All the species' genomes used in the study have been published and are available for public use, with the exception of two species, *C. wieringae* and *N. vishniacii*, and permission to use these two species' CYPs was obtained from the principal investigators listed at the respective species' databases at the Joint Genome Institute MycoCosm portal [8].

**Table 2.** Species of *Tremellomycetes* used in the study. The respective genome databases used for analysis of CYPs, along with the reference articles, are listed in the table. Abbreviations: NCBI, National Center for Biotechnology Information and JGI, Joint Genome Institute.

