*4.8. Prediction the Interaction of Tertiary Structure of CYP6FD1 and CYP4FD2 with Sulfoxaflor*

To obtain information about how sulfoxaflor affects P450s, molecular docking between sulfoxaflor and the active sites of the target P450 proteins was carried out using the Surflex-Dock program in SybylX-2.0 version (Tripos Inc.) as previously described [50]. Surflex-Dock scores (total scores) were expressed in kcal/mol units to represent binding affinities [51,52].
