**About the Editors**

**Patrick M. Dansette** is Director of Research Emeritus at CNRS UMR 8601, University of Paris. He is 75 and has 54 years of research experience. He is a chemical engineer (ESCIL, CPE-Lyon) and obtained his PhD in biochemistry in ORSAY (1972). Since his work at NIH with JW Daly and Don Jerina and after 1977 with D. Mansuy, he has been involved in the study of xenobiotic-metabolizing enzymes and reactive metabolites (arene oxides, thiophene sulfoxides, sulfenic acids, and other electrophiles). In 1987, with Ph. Beaune, he first demonstrated that auto-antibodies in drug-induced hepatitis (tienilic acid, TA) are directed against a cytochrome P450 (CYP2C9) and that TA is a mechanism-based inactivator. He also showed that ticlopidine is a mechanism-based inhibitor of CYP2C19. Together with EF Johnson, he has studied the active site topology of several CYP 2Cs using a family of substrates and inhibitors, NMR relaxation methods, computer modeling, and crystallization. He demonstrated the pharmacological activation pathway of antithrombotic agents Ticlopidine, Clopidogrel and Prasugrel via a sulfenic acid-reactive intermediate and extended the studies on sulfenic acid intermediates in drug metabolism. He has also studied the metabolism of ferrocifens, ferrocenyl analogs of tamoxifen, as anticancer compounds. Finally, with Jean-Luc Boucher, he studied the metabolism of dithiolethiones and their involvement in H2S production.

**Dani `ele Werck-Reichhart** is Emeritus Research Director at the CNRS Institute of Plant Molecular Biology, University of Strasbourg. She has published more than 120 papers related to plant cytochrome P450 enzymes and performed pioneering work in the field in connection with phenolic and terpenoid plant metabolism, as well as herbicide detoxification. She is an elected member of EMBO.
