**6. Conclusions**

In the pursuit of improved cancer therapeutics, the use of GNPs offers the potential of improving on many different facets of the treatment process. Despite progress, the translation of GNPs to clinical practice has been limited due to the lack of coordination between researchers and clinicians. Many advances covered in this review aim to address issues that have arisen in the past, including targeted therapy, and the combination of radiotherapy and chemotherapy paired with GNPs for improved efficacy. However, it is still important to improve upon the current research so that translation to the clinic can be expedited.

**Author Contributions:** All authors have made substantial contributions in preparation of the manuscript. All authors agreed to be personally accountable for the author's own contributions and to ensure that the questions related to the accuracy or integrity of any part of the work, even ones in which the author was not personally involved, are appropriately investigated, resolved, and the resolution agreement published in the literature. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by Natural Sciences and Engineering Research Council of Canada (NSERC), grant number 418453.

**Acknowledgments:** The authors would like to acknowledge Canada Foundation for Innovation (CFI), the British Columbia government, Natural Sciences and Engineering Research Council of Canada (NSERC), British Columbia Cancer, Vancouver Island (BCC), Centre for Advanced Materials and Related Technologies (CAMTEC), and University of Victoria for their financial support.

**Conflicts of Interest:** The authors declare no conflict of interest.
