*2.2. Cardiovascular Disease*

Cardiovascular disease, another fatal ailment, has a strong association with ROS during the development stage [31]. The overproduction of ROS in vascular cells during the reactions involving enzymes like NADPH oxidase, nitric oxide synthases causes the modification in low-density lipoproteins (LDL) [32]. Furthermore, ROS are also found to be involved in cardiac hypertrophy development, myocyte apoptosis and ischemia-reperfusion injury, which ultimately lead to cardiac arrest [33–35].
