*2.12. Histopathology*

Mice were sacrificed and transcardially perfused with 4% paraformaldehyde (PFA) in PBS 15 days after treatment. The tumors were dissected and post fixed overnight in 4% PFA. The tumor tissue was embedded in paraffin and sectioned into 5 μm slices, stained with hematoxylin and eosin (H&E) and visualized with a Mirax desk scanner (Zeiss, Jena, Germany). In addition to histopathology, TEM analysis was performed on the tumor tissue following the protocol supplied in the supplementary information of Trekker et al. [45].
