*Review* **A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications**

**Humaira Idrees 1,\*, Syed Zohaib Javaid Zaidi 2,\*, Aneela Sabir 1, Rafi Ullah Khan 1,2, Xunli Zhang <sup>3</sup> and Sammer-ul Hassan 3,\***


Received: 4 August 2020; Accepted: 28 September 2020; Published: 5 October 2020

**Abstract:** Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

**Keywords:** polymers; biodegradable; nanoparticles; drug delivery; pharmaceutical
