**pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery**

**Evgeny Apartsin 1,2,3,\*, Nadezhda Knauer 1,4, Valeria Arkhipova 1,2, Ekaterina Pashkina 1,4, Alina Aktanova 1,4, Julia Poletaeva 1, Javier Sánchez-Nieves 5,6, Francisco Javier de la Mata 5,6,7 and Rafael Gómez 5,6,7,\***


Received: 7 August 2020; Accepted: 22 September 2020; Published: 23 September 2020

**Abstract:** Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

**Keywords:** carbosilane; dendron; triazine; amphiphile; self-assembly; vesicles; pH-sensitive; doxorubicin; methotrexate; leukaemia
