*2.2. Non-Biodegradable Polymer Properties*

Clinically non-biodegradable polymers are used for local injection of antibodies. Mostly non-biodegradable polymers such as acrylic polymers, cellulose derivatives, silicons, etc. are mentioned in Figure 2 in the introduction section. Polymethyl methacrylate (PMMA) is an acrylic-based non-biodegradable polymer that is mostly used for implantation as bone cement or in the form of PMMA beads. While widely used, PMMA has many disadvantages: it is a substrate for bacterial colonization, has low biocompatibility, is non-biodegradable in bead form, the release of antibiotic decreases with time, it is not heat resistant, it has fewer antibiotic elimination properties, delivery of the antibiotic, it has a variable surface area which results in uneven release rates. Due to the disadvantages of non-biodegradable polymers, scientists are interested in developing biodegradable, biocompatible polymer synthesis for a drug delivery system [37]. The main objective of this review is to study the role of five biodegradable polymers in a drug delivery system.
