*2.1. General Remarks*

Buffers composition: TA—50 mM Tris-Acetate, pH 7.5; TAM—50 mM Tris-Acetate, pH 7.5, 15 mM MgCl2; TAN—50 Tris-Acetate, pH 7.5, 100 mM NaCl. All buffers were filtered through 0.22 μm Millipore Syringe Filter units (Merck, KGaA, Darmstadt, Germany, and/or its affiliates). Oligonucleotides and DOCs were incubated in 1.5 mL DNA LoBind tubes (Eppendorf AG, Hamburg, Germany).
