**1. Introduction**

The use of engineered nanosized constructions as drug delivery systems has become an emerging area of attention in recent years due to their ability to improve pharmacological properties of cargo compounds, i.e., improving selectivity and efficiency of drug delivery into target cells/tissues, reducing off-target effects of drugs, and protecting drugs from the biological environment amid the delivery [1]. Furthermore, nanoconstructions are expected to release a cargo in a controllable manner upon the action of external stimuli (changes of ambient pH or temperature, enzymatic digestion etc.) [2]. In light of this, the use of supramolecular assemblies for drug delivery seems to be very promising [3].

Dendritic molecules, dendrimers and dendrons, are versatile platforms to design supramolecular nanoconstructions for robust drug delivery [4–8]. In particular, carbosilane dendrimers are efficient tools for antibacterial [9] and antiviral therapy [10], nucleic acid delivery [11], cancer treatment [12], imaging [13], functional nanomaterials [14,15], and so on. It should be noted that dendritic architectures give room to design various types of supramolecular constructions based on the molecular topology of building blocks. Systematic studies conducted using amphiphilic dendrons revealed the effect of both the structure of the hydrophobic part and the dendron generation as amphiphilic part on their assembly into supramolecular constructions of given topology: micelles, unilamellar or multilamellar vesicles [16–18]. These regularities are implemented in the development of dendron-based nanoconstructions for biomedical applications [19–23].

To increase the loading capacity, the formation of vesicle-like assemblies (dendrimersomes) is preferred over micelle-like ones. This can be achieved by branching the hydrophobic part in the focal point of dendron. In this work, we suggest the use of a triazine moiety as a branching point. Triazine-based synthons can be easily prepared by the controllable substitution in cyanuric chloride [24]; they have already been shown to be versatile building blocks both for building dendrimer scaffolds [25] and for the functionalisation of dendrimer surface [26]. Furthermore, triazine cycle gets protonated in slightly acidic medium (pH~5.5) [27], which can be useful for the design of pH-sensitive constructions [28].

Herein, we report the synthesis of a new class of functional dendritic species—amphiphilic triazine-carbosilane dendrons. We aim to study the self-assembly of dendrons in physiological conditions as well as to explore the potential of dendrons' self-assemblies for drug delivery. As a representative and emerging model, leukaemia cell lines have been chosen. Leukaemia is a severe cancer of frequent occurrence. At present, despite advances of chemotherapy, the survival rate in adult patients with acute lymphoblastic leukaemia does not exceed 50% [29]. The prognosis for chronic leukaemia is more favorable; however, some aggravations, so-called blast crises that require special treatment may occur [30]. In view of this, the development of novel approaches to increase the efficacy of chemotherapy, in particular, nanomedicine-based ones, is highly important.
