2.5.2. 2,4-dodecylamino-6-piperazino-1,3,5-triazine

2,4-didodecylamino-6-chloro-1,3,5-triazine (600 mg, 1.2 mmol) and piperazine (645 mg, 7.5 mmol) were mixed in 15 mL CHCl3; the reaction mixture was stirred at room temperature. When the starting triazine derivative was fully consumed, as shown by TLC (5% CH3OH in CH2Cl2), the solution was washed several times with 1M NaOH, then with water. The organic phase was separated, dried over Na2SO4, and the solvent was removed under vacuum to yield the desired product as yellowish solid (600 mg, 92%).

1H NMR (400 MHz, CDCl3) δ 0.87 (t, J = 6.5 Hz, 6H, Ha), 1.20–1.37 (m, 36H, Hb, Hc), 1.52 (t, 4Hd), 1.81 (s, 1H, Hi), 2.85 (s, 4H, Hh), 3.33 (d, 4H, Hg), 3.72 (s, 4H, He), 4.75 (s, 2H, Hf). 13C NMR (101 MHz, CDCl3) δ 14.1, 22.7, 27.0, 28.6–30.3 (m), 31.9, 40.7, 44.2, 46.1, 165.2, 166.3. MS: [M + H]<sup>+</sup> 532.51 amu (calcd 531.50 amu).
