*2.7. Characterization of Assembled DOCs Micellar Structures by TEM*

Dodecyl oligonucleotide conjugates were diluted to 5 μM in TAM buffer. The reactions were equilibrated for 3 h at 25 ◦C before a drop of this sample was adsorbed for 1 min on the copper grid covered with formvar film which was stabilized using carbon evaporation. Then excess of liquid was removed with filter paper, and a grid was placed for 5–10 s on a drop of 1% uranyl acetate, excess liquid was collected with filter paper. All grids were examined using a transmission electron microscope JEM-1400 (JEOL, Tokyo, Japan), and images were obtained using a Veleta (EM SIS, Münster, Germany) digital camera. All measurements were made using program package iTEM (EM SIS, Münster, Germany).
