**Advances in Lipidomics: Biomedicine, Nutrients and Methodology**

Editors

**Olimpio Montero David Balgoma Luis Gil-de-G ´omez**

MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade • Manchester • Tokyo • Cluj • Tianjin

*Editors* Olimpio Montero Spanish National Research Council (CSIC) Spain

David Balgoma University of Uppsala Sweden

Luis Gil-de-Gomez ´ Children's Hospital of Philadelphia USA

*Editorial Office* MDPI St. Alban-Anlage 66 4052 Basel, Switzerland

This is a reprint of articles from the Special Issue published online in the open access journal *Metabolites* (ISSN 2218-1989) (available at: https://www.mdpi.com/journal/metabolites/special issues/advances lipidomics).

For citation purposes, cite each article independently as indicated on the article page online and as indicated below:

LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. *Journal Name* **Year**, *Volume Number*, Page Range.

**ISBN 978-3-0365-1186-3 (Hbk) ISBN 978-3-0365-1187-0 (PDF)**

© 2021 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications.

The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND.

## **Contents**



### **About the Editors**

**Olimpio Montero**'s research is focused in mass spectrometry-based metabolomics with a special focus in lipidomics. He has worked in diverse research centers and institutes, as well as collaborated with groups specializing in different areas of mass spectrometry, metabolomics, and lipidomics. Dr. Montero has published about 60 scientific documents, including journal articles and book chapters. Currently member of the Metabolomics Society, he has reviewed more than 70 papers for about 20 different scientific journals.

**David Balgoma** is a researcher at Uppsala University. His areas of expertise are mass spectrometry and lipidomics with a focus on data pre-treatment and statistical analysis.

**Luis Gil-de-G ´omez** has developed a research portfolio in the study of how metabolism shapes the innate and adaptive immune response in diverse diseases, including Alzheimer's disease, malnutrition, and cancer. He is experienced in chromatography, mass spectrometry, and flow cytometry techniques. Based on these platforms, the impact of cellular metabolic state has been studied with different approaches: lipidomic profiling of the inflammation process, diagnosis method based on alterations of plasma metabolites, the interaction of the gut microbiota with the immune response, and the metabolic reprogramming on the immunity activation and immune tolerance balance.

## **Preface to "Advances in Lipidomics: Biomedicine, Nutrients and Methodology"**

Lipidomics, a primary branch of metabolomics, have rapidly developed into a novel research discipline. This feature has arisen from robust evidence of lipid reprogramming in metabolic disorders, cancer, or cardiovascular diseases. The importance of the lipid composition in a variety of pathologies has been elucidated from alternative perspectives. This book contains studies regarding lipidomics methodology, the involvement of lipids in metabolism and biomedicine, and advances in nutrition.

Regarding advances in methodology, Panzenobeck et. al. automated the annotation of glycosylinositolphosphoceramides in plants. Jenkins et al. presented a high-throughput method of lipid extraction. Magny et al. combined the prediction of molecular behavior with mass spectrometric data in order to annotate lipids. Regarding advances in lipid metabolism in biomedicine, Saito et al. reported the lipid profile associated to liver injury induced by drugs. Franco et al. investigated the sexual dimorphism in mouse epidermis of phospholipids, cholesteryl esters, acylcarnitines, and sphingolipids. Azbukina et al. profiled oxylipins in plasma from patients with Wilson disease. Miehle et al. studied the remodeling of lipids during adipogenesis. Korczynska et al. profiled fatty acids in ´ serum from patients with chronic kidney disease. Balgoma et al. reviewed the involvement of lipids in human positive ssRNA virus infection. Gil-de-Gomez et al. reviewed the potential of lipids to ´ modulate the immune response in cancer. Tomczyk et al. reviewed the lipidome profile in models of cardiovascular disease. Finally, regarding nutrition and biomedicine, Ferreri et al. reviewed the relationship between the lipidome, nutrition, and signaling metabolic pathways in cancer.

The reader interested in a broad perspective of lipidomics and the involvement of the lipidome in different diseases will find this book interesting in order to obtain state-of-the-art applications and discoveries.

> **Olimpio Montero, David Balgoma, Luis Gil-de-G ´omez** *Editors*

*Article*
