*4.2. Suitability of the HPLC Method for Rivastigmine Quantification*

The developed HPLC method was considered to be simple, linear, precise, selective, reproducible, and robust (Supplementary Data, Sections 1 and 2) for rivastigmine quantification. A good linearity (*R* <sup>2</sup> = 0.999) was observed in the tested range, with RSD values lower than 1% and a recovery rate close to 100% being obtained. Furthermore, the values obtained for the detection and quantification limits were suitable for application of the method. The selectivity for rivastigmine quantification in the presence of other formulation components was also demonstrated and the results of encapsulation parameters showed that NLCs are effective for rivastigmine encapsulation.
