*3.1. Influence of Temperature on FEN Solubility in Lipids*

In order to select the optimum lipids for supersaturating FEN, solubility studies were performed at 25, 40, and 60 ◦C in Capmul PG8 (PG8), Captex 300 (C300) and Capmul MCM (MCM). It was evident that FEN solubility in all lipids increased considerably with temperature, achieving 4.4- to 7.7-fold greater FEN solubility at 60 ◦C compared to 25 ◦C (Figure 1). Regardless of temperature, FEN displayed greatest solubility in PG8, achieving a solubility of 98 ± 3.5 mg/g at 25 ◦C and 516 ± 29.5 mg/g at 60 ◦C. PG8 and C300 were chosen for the fabrication of FEN-loaded SLH due to both lipids exerting the highest drug loading at 60 ◦C. MCM was excluded due to its inferior drug loading capacity.

**Figure 1.** The temperature-dependent solubility of fenofibrate (FEN) in Capmul MCM (grey bars), Captex 300 (orange bars), and Capmul PG8 (green bars). Values represent mean ± SD, *n* = 3. **Figure 1.** The temperature-dependent solubility of fenofibrate (FEN) in Capmul MCM (grey bars), Captex 300 (orange bars), and Capmul PG8 (green bars). Values represent mean ± SD, *n* = 3.
