2.4.5. Stability Studies

The physical stability of the vesicles was checked weekly during 60 days in terms of size and PDI by DLS. The stability of the vesicle suspensions was determined using TurbiscanTM LAB Stability Analyzer (Formulaction SA, L'Union, France) by checking the phenomena of coalescence, flocculation, creaming, sedimentation, and clarification during the 24 h after the suspension was formulated [55]. The chemical stability of the B12 was assessed by determination of drug content every week for 3 months.
