PDI, ZP, and EE

The results showed that the values obtained for PDI, ZP, and EE (Figure 3D–F) did not change significantly with variations of the emulsification speed and sonication amplitude, as observed for the HPH method. PDI values were between 0.21 and 0.25, while ZP ranged between −26 mV and −28 mV. The EE values ranged from 95% up to 97%, being close to 99% for 14,000 rpm with 55% amplitude. The small differences in ZP and EE values can be attributed to the different locations of the anionic drug molecules in the lipid matrix [32,46].
