*2.1. Materials*

Precirol ATO 5® (glycerol disterate) (pharma grade) and Mygliol® (caprylic/capric triglyceride) (pharma grade) were a kind gift from Gattefosé (Lyon, France) and IOI Oleo GmbH, respectively. DHA (80% purity) and DHAH (85.4% purity) fatty acids in ethyl ester and triglyceride form were purchased from Medalchemy (Alicante, Spain). They were aliquoted in topaz vials in N<sup>2</sup> inert atmosphere conditions ready for one unique use in order to avoid oxidation during storage over the course of the experiment. Tween 80, Tween 20 and 3.7% paraformaldehyde were purchased from Panreac (Barcelona, Spain). Lutrol® F-68 (Poloxamer 188) (FDA-approved excipient) was acquired from VWR Avantor (Barcelona, Spain). Chitosan (CS) was obtained from NovaMatrix (Sandvika, Norway). Trehalose dehydrate, Triton X-110, bovine serum albumin (BSA), poly-l-lysine hydrobromide (PLL), deoxyribonuclease I from a bovine pancreas (DNase I), 6-hydroxydopamine hydrochloride (6-OHDA), Cell Counting Kit-8 (CCK-8), 2,20 -Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and FluoromountTM Aqueous Mounting Medium were acquired from Millipore Sigma Life Sciences (Madrid, Spain). Additionally, 40 ,6-diamidino-2-phenylindole (DAPI), donkey anti-mouse IgG (H+L) cross-adsorbed secondary antibody, Alexa Fluor 555, goat anti-rabbit IgG (H+L) cross-adsorbed secondary antibody and Alexa Fluor 488 were purchased from Thermo Fisher Scientific (Madrid, Spain). NeurobasalTM medium, B-27TM supplement, glutamine 100X, penicillin-streptomycin (P/S), fetal bovine serum (FBS), DMEM GlutaMAXTM, trypsin-EDTA 0.25% and Hank's Balanced Salt Solution (HBSS)

were obtained from Gibco© by Life Technologies (Madrid, Spain). Anti-tyrosine-hydroxilase (TH) primary antibody and anti-glial fibrillary acidic protein (GFAP) primary antibodies were obtained from Abcam (Cambridge, UK). Anti-Iba1 (ionizing calcium-binding adaptor molecule 1) primary antibody was purchased from Synaptic Systems (Göttingen, Germany). Lipopolysaccharide (LPS) suitable for cell culture was bought from InvivoGen (Toulouse, France). Rat IL-6 Standard, Rat IL-1β Standard and Rat TNF-α Standard ABTS ELISA Development Kits were obtained from Peprotech (London, UK). Finally, TAT (>95% purity) was obtained from ChinaPeptides (Suzhou, China). All reagents used were of analytical grade.
