**5. Summary**

Our group has examined the fluorescence detection of phase transformation dynamics with symmetry breaking of organic compounds by photochemical methods. The phase transformation process was confirmed based on the fluorescence color change in real-time. In particular, the intermediate state (the liquid-like cluster) was visualized during the evaporative crystallization for the first time. Since this method can be carried out with a fluorescence microscope or a general optical system, it is advantageous that the experimental apparatus is relatively inexpensive. To clarify the inhomogeneity and propagation of the phase transformation process in real-time symmetry breaking, we will utilize a time- and space-resolved phase transformation detection system based on the hyperspectral camera imaging of the fluorescence spectra.

**Funding:** This research was funded by the Nanotechnology Platform Program and by JSPS KAKENHI grant numbers JP21750021, JP15H01081, JP17H05253, JP19H02686.

**Acknowledgments:** The authors thank Takehiro Sagawa, Jun-ichi Fujimori, Yukino Suzuki, Mai Saigusa, and Naoki Kanayama (Shinshu University); Atsushi Sakai and Hiroshi Ikeda (Osaka Prefecture University); Yudai Ogata and Keiji Tanaka (Kyushu University); Mitsuo Hara and Takahiro Seki (Nagoya University); and Ryohei Yasukuni and Marc Lamy de la Chapelle (Paris 13 University) for their support with the experiments and kind discussion. We also thank Kennosuke Itoh (Shinshu University) for the NMR measurements.

**Conflicts of Interest:** The authors declare no conflict of interest.

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