*3.6. Synthesis of Other Nanoparticles*

### 3.6.1. Iron Nanoparticles (FeNPs)

FeNPs were intracellularly synthesized by using hypha of *Pleurotus* sp. The reduction process is involved in uptake of FeNPs via the fungal cell membrane, in which reduction of ferric ion (Fe+<sup>3</sup> ) to ferrous ion (Fe+<sup>2</sup> ) takes place. The reduction process is involved during the iron uptake by fungi [83].

### 3.6.2. Selenium Nanoparticle (SeNP)

SeNPs were synthesized via mushroom polysaccharide-protein complexes (PSPs) isolated from *P. tuber-regium* sclerotia. These NPs have anticancer activity, excellent bioavailability, and low toxicity. SeNPs have been recorded for inhibiting the proliferation of human breast carcinoma MCF-7 cells by apoptosis; results obtained from the study revealed that cytotoxicity was cancer-specific [84]. PSP–SeNPs have the efficiency to enhance the reactive oxygen species (ROS) generation, and inhibit dose dependently the growth of MCF-7 human breast carcinoma cells, through induction of apoptosis, with the involvement of Poly (ADP-ribose) polymerase (PARP) cleavage and caspase activation. The size of PSP–SeNPs with an average diameter < 50 nm spherical in shape [85]. The synthesis of SeNPs from *P. ostreatus* extract have been reported for in vitro anticancer activity [86].
