*4.7. Other Nanoparticle Activity*

Salaheldin et al. [119] reported that AgNPs synthesized by *F. oxysporum* caused remarkable vacuolation in the human breast carcinoma cell line (MCF-7), thus indicating potent cytotoxic activity. Al-Sharqi [168] tested these mycogenic AgNPs on mice for 21 days and showed dilation in the collecting tubule and dilation in the renal corpuscle with haemorrhage in the interstitial space between the tubules. Based on performed studies, the authors conclude that AgNPs can enter and translocate within the cell, and that the size of the AgNPs varies with its toxic effects on the cell and the cell organelles. Therefore, it was assumed that all nanoparticles are toxic and most likely only free nanoparticles that can penetrate small organelles such as mitochondria may trigger adverse health effects [168].
