3.1.4. Nanocomposites for Antifungal Drug Delivery Agents

The nanocomposites of natural materials such as carbohydrates and proteins with polymers have the ability of effectively releasing of these materials at targeted sites [40]. However, the modified CS NPs are capable of drug delivery to diseased tissues at lower doses than traditional chemical cancer therapy. They can be used as an adjuvant for effective animal vaccination against infections. The parental administration of nanoshells comprised of silica core attached with metals NPs and drugs in animals can be useful to search and can be directed to target cancer cells [90].

The nanocomposites qualify quite uniquely considering the non-stimulation of the elaborate immune response aspect [91]. The embedding or encapsulation of the drug in polymer blend-based nanocomposite also improves its antifungal potential. Terbinafine hydrochloride was introduced into the polycaprolactone (PCL)/gelatin nanofibers generated by the hydrothermal method [92]. The resulting wound dressings were tested for their antifungal potential.The researchers were successful in inhibiting the *T. mentagrophytes* and *Aspergillus fumigatus* due to slow release of the embedded drug molecules from the nanocomposite fibers over time [92].
