**Frontal EEG Changes with the Recovery of Carotid Blood Flow in a Cardiac Arrest Swine Model**

**Heejin Kim <sup>1</sup> , Ki Hong Kim <sup>2</sup> , Ki Jeong Hong <sup>2</sup> , Yunseo Ku 3,\* , Sang Do Shin <sup>2</sup> and Hee Chan Kim <sup>4</sup>**


Received: 17 April 2020; Accepted: 25 May 2020; Published: 28 May 2020

**Abstract:** Monitoring cerebral circulation during cardiopulmonary resuscitation (CPR) is essential to improve patients' prognosis and quality of life. We assessed the feasibility of non-invasive electroencephalography (EEG) parameters as predictive factors of cerebral resuscitation in a ventricular fibrillation (VF) swine model. After 1 min untreated VF, four cycles of basic life support were performed and the first defibrillation was administered. Sustained return of spontaneous circulation (ROSC) was confirmed if a palpable pulse persisted for 20 min. Otherwise, one cycle of advanced cardiovascular life support (ACLS) and defibrillation were administered immediately. Successfully defibrillated animals were continuously monitored. If sustained ROSC was not achieved, another cycle of ACLS was administered. Non-ROSC was confirmed when sustained ROSC did not occur after 10 ACLS cycles. EEG and hemodynamic parameters were measured during experiments. Data measured for approximately 3 s right before the defibrillation attempts were analyzed to investigate the relationship between the recovery of carotid blood flow (CBF) and non-invasive EEG parameters, including timeand frequency-domain parameters and entropy indices. We found that time-domain magnitude and entropy measures of EEG correlated with the change of CBF. Further studies are warranted to evaluate these EEG parameters as potential markers of cerebral circulation during CPR.

**Keywords:** cardiopulmonary resuscitation (CPR); electroencephalogram (EEG); hemodynamic data; carotid blood flow (CBF); cerebral circulation
