**Controlled Stepwise Synthesis and Characterization of a Ternary Multicomponent Crystal with 2-Methylresorcinol**

### **Daniel Komisarek 1, Carsten Schauerte 2 and Klaus Merz 3,\***


Received: 6 February 2020; Accepted: 28 February 2020; Published: 4 March 2020

**Abstract:** A typical approach of a multicomponent crystal design starts with a retrosynthetic analysis of the target molecule followed by a one-pot reaction of all components. To develop protocols for multicomponent crystal syntheses, controlled stepwise syntheses of a selected crystalline ternary multicomponent system **1** involving 2-methylresorcinol (MRS), tetramethyl-pyrazine (TMP), and 1,2-bis(4-pyridyl)ethane (BPE) are presented. The obtained binary cocrystals **2** (involving MRS and TMP) and **3** (involving MRS and BPE) as well as the final resulting ternary multicomponent system **1** were characterized by X-ray analysis.

**Keywords:** multicomponent cocrystal; cocrystallization mechanism; cocrystal synthesis
