*4.1. Patient Characteristics*

The clinical characteristics of the 233 included patients are summarized in Table 1. From 2015 to 2018, 233 patients for staging and restaging were retrospectively evaluated. [68Ga]Ga-PSMA-11 PET/CT of 215 BC patients who had previously undergone either radical prostatectomy (178, patient group P-P, PSA elevation to >0.2 ng/mL by definition) or radiation therapy (37, patient group P-I, PSA elevation to >2 ng/mL above nadir by definition) and 18 patients with elevated PSA serum level of >4.0 ng/mL, highly suspicious of having primary PCa (group P-T) were separately assessed [15]. All PSMA-positive lesions of P-T were histopathologically confirmed as PCa by biopsy. In case of BC (P-P, P-I), when the biopsy or surgery of PSMA-avid lesions was not possible or considered too invasive for the patients (e.g., bone metastases), we rated the increase of PSA before therapy and decrease after therapy as a tumor confirmation and marker. Additionally, we have included the findings of follow-up examinations (such as PSMA PET/CT, PSMA PET/MRI, CT, MRI).

This retrospective study was done in accordance with the Declaration of Helsinki. All reported investigations were conducted according to the national regulations (German Medical Products Act, AMG § 13.2b). The protocol was approved by the Ethics Committee of Laek Rlp (2018-13390). All patients signed an informed consent (including participation in the study and for evaluation and publication of their anonymized data).
