*4.1. Data Mining of GSE31684 to Identify Altered Gene Expression in UC*

The transcriptome dataset GSE31684 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc= GSE31684), which includes 93 patients with UBUC who underwent radical cystectomy, was obtained from the Gene Expression Omnibus repository at the National Center for Biotechnology Information. Raw data were imported by Nexus Expression 3 (BioDiscovery, EI Segundo, CA, USA) to quantify the gene expression level. No pre-selection or filtering was conducted during the analysis of the data for all probes. Comparative analyses were performed to determine the significant differences in the expressed genes by comparing the primary tumor (pT) status (high-stage to low-stage) and the presence or absence of metastatic events.
