**Table 2.** *Cont.*

Certainly, the juice is the most widespread type of pomegranate-based product in stores for its ease of consumption, followed by capsules with a concentration of ellagic acid of 40% [3]. From what emerges from the various studies analyzed, the interest in the consumption and production of pomegranate has greatly increased in recent years [172–175].

Indeed, prior research has thoroughly supported the beneficial e ffects of pomegranate regarding not only the phytocomplex, but also the single components, among which the various tannins and the ellagic acid stand out. However, several studies stated that the synergistic potential of all pomegranate components (for example phenolic compounds) is powerful to that of single constituents [176–178]. Precisely, the latter has recently aroused grea<sup>t</sup> interest for the potential inhibitory activity against Sars-CoV-2, demonstrated through docking studies and, for this reason, it seems clear that continuing the research with the evaluation of the activity could represent an important goal for the fight against this plague [131,133].

Moreover, much research has promoted the possible employment of pomegranate together with other drugs already available (like doxorubicin), establishing its good influence in reverting their chemoresistance, thus overcoming their limits, lowering the toxicity, and increasing the action.

In light of the reasons mentioned above, it becomes evident that pomegranate turns out to be one of the most attractive nutraceuticals, and the deepening of its study could lead to the opening of new avenues for medical science domains.

**Author Contributions:** Conceptualization, A.C. (Anna Caruso) and A.B.; methodology, D.I.; software, J.C.; validation, A.F. and C.F.; resources, A.T. and G.B.; data curation, A.C. (Alessia Catalano); writing—original draft preparation, A.C. (Anna Caruso) and A.B.; writing—review and editing, A.C. (Alessia Carocci) and D.I.; supervision, M.S.S. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding

**Conflicts of Interest:** The authors declare no conflict of interest.
