*2.1. Materials*

Bicalutamide (BCL, 99.3% purity, Hangzhou Hyper Chemicals Limited, Hangzhou, China) was used as an active substance: molecular formula C18H14F4N2O4S, molecular weight 430.4 g/mol, solubility in water 3.7 μg/mL, logP = 2.92, pKa = 12.6, melting point 196 ◦C. Macrogol 6000 (PEG6000, Clariant, Muttenz, Switzerland): molecular formula H(OCH2CH2)nOH, average n = 100, nonionic substance, melting point 65 ◦C, and Poloxamer® 407 (PLX407, BASF, Ludwigshafen am Rhein, Germany), molecular formula HO(C2H4O)a(C3H6O)b(C2H4O)aH a = 101, b = 56; average molecular weight 9840–14,600 g/mol, melting point 55 ◦C, freely soluble polymers were used as carriers. Carbon dioxide (CO2; 99.99% purity, Pszczyna, Linde Gaz, Poland) was used as a supercritical fluid. Sodium lauryl sulfate (SLS; 98.8% purity; BASF) was used to prepare dissolution medium. Distilled water was used to prepare all the solutions. Cellulose microcrystalline (JRS Pharma, Rosenberg, Germany), sodium starch glycolate (DFE Pharma, Goch, Germany) and magnesium stearate (Merck, Darmstadt, Germany) were used as excipients to formulate tablets. All excipients used to formulate tablets were of pharmaceutical grade.
