*1.6. Triggers*

There are different ways to disintegrate CORMs/CORMats for the release of CO moiety by means of; peculiar physiological conditions [52], trigger by temperature [53], activation by an enzyme [54], pH alteration and increase in reactive oxygen species (ROS) concentration, accessibility to distinct wavelength of light [55,56], either using thermal degradation or ligand exchange/substitution or both [53] and prototypically activation through oxidation mechanism [11,57,58]. In order to deliver the CO molecules at a specified therapeutic rate, it is necessary to characterize the CORMs and CORMats entities, as quantification of such mechanisms might be contingent with its physical conditions like O2, temperature, assay solution and light conditions.
