**4. Conclusions**

This study has examined the effect of supercritical carbon dioxide treatment on the properties of binary systems containing bicalutamide and Macrogol 6000 or Poloxamer® 407. The dissolution and attributes of tablets were evaluated. The scCO2 influenced not only the size and shape of the particles of the processed substances, but also the dissolution characteristics of bicalutamide from solid dispersions. Supercritical conditions induced a decrease in the crystallinity of the active substance. The obtained solid dispersions were successfully formulated in tablets. The tableting process induced the amorphization of the drug substance. This phenomenon confirmed the sensitivity of bicalutamide on mechanical activation. After 1h, the amount of bicalutamide dissolved from tablets with PEG6000 remained unchanged. In the case of tablets containing Poloxamer®407, the amount of released substance decreased by 20%. However, the compression affected the dissolution profiles of the drug substance in comparison with solid dispersion. The stability studies indicated that storage conditions affected the tablets' properties. The amount of the released drug decreased regardless of the storage conditions. However, in the stability studies after six months, the diffraction patterns did not change, which indicated that the physical state of the active substance was unchanged.

**Author Contributions:** A.A.-R.—writing original draft, investigation; J.S.-S.—writing, review and editing, investigation; K.C.—investigation; J.K.-K.—investigation; M.K.—investigation; K.G.—investigation; V.P.D.—investigation; M.P.—conceptualization, project administration; R.J.—conceptualization, review, supervision. All authors have read and agreed to the published version of the manuscript.

**Funding:** The authors acknowledge the Polish National Science Centre for the financial support (grant Symfonia 3 no 2015/16/W/NZ7/00404).

**Conflicts of Interest:** The authors declare no conflict of interest.
