*2.9. Nanosheets*

The encapsulation of CORM's commodity shows promising features. X. Chen et al. worked out to cage the Manganese-carbonyl CORM inside the small MnCO-graphene oxide (PEG-BPY[MnBr(CO)3]-GO) nanosheet, recruited as a drug carrier trigger by NIR light energy with on-demand CO release for photochemical CORMats [48]. They successfully constructed the novel combinations of the CO-release mechanism but triggered facility provided inconvenience for therapeutic purposes. However, we also need to pay attention to its complete managemen<sup>t</sup> system, as in some cases big trouble may be faced for its state of being clinically applied or not. Merely an advantage for the CO releasing behavior is not enough, as it will always be difficult to handle it and nearly impossible for remote area patients, thus it raises a concern for being a practically viable medicine or not. Moreover, there might be no concern to what happens to metal degradation and leftover residue, which actually needs to be addressed properly too. Apart from this, how can we provide this medication to the patient using NIR trigging, so its mobility will remain the utmost challenge. In reality, the novel production in terms of its laboratory scale is quite different from its practical application as a cure agent.
