*2.8. Statistical Analysis*

Statistical analysis of the obtained results was carried out with the R software environment for statistical analysis (version 3.2; https://www.R-project.org/). To evaluate the significance of the differences among the groups, the Kruskal–Wallis test was applied. Pair-wise distribution comparison of the analyzed indices in the experimental and control groups was conducted using one-sided Mann–Whitney test. When multiple testing, FDR procedure was performed to correct *p*-values.
