**Appendix A**

The inclusion and exclusion criteria used in the study:

	- Informed consent to participate in the study;
	- HIV positive men and women over 18 years old receiving stable first-line ART for at least 6 months and not more than 2 years;
	- Stable clinical course of HIV infection (clinical stage 1 or 2 according to WHO classification);
	- HIV viral load less than 50 copies/mL at screening;
	- Number of CD4 T cells more than 250 cells/mm<sup>3</sup> at screening;
	- blood parameters: leukocytes—≥2900/mm<sup>3</sup> (2.9 <sup>×</sup> 109 cells/L), absolute neutrophil count—≥1500/mm3 (1.5 <sup>×</sup> 10<sup>9</sup> cells/L), platelets—≥100,000/mm<sup>3</sup> (100 <sup>×</sup> 109 cells/L), hemoglobin—≥9.0 g/dL, bilirubin—≤1.5 × upper limit of normal, ALT and AST—≤2.5 × upper limit of normal;
	- Glomerular filtration rate (GFR)—>60 mL/min.
	- Consent to use adequate contraceptive methods throughout the study (condom with spermicide).
	- Acute hepatitis or cirrhosis of any etiology; anti-HCV or HBsAg, at screening;
	- Opportunistic infections that meet the Category C classification of the Centers for Disease Control and Prevention (CDC) of 2008, with the exception of Kaposi's sarcoma that does not require systemic therapy;
	- Tuberculosis;
	- Malignant neoplasms;
	- Participation in other clinical studies within 3 months before screening;
	- Reception of immunomodulators (interferons, interleukins), immunosuppressive (cyclosporine), glucocorticosteroids within 3 months before screening;
	- Any vaccination within 6 months before screening;
	- Significant alcohol or drug addiction;
	- Hypersensitivity to any component of the study vaccine;
	- Severe concomitant diseases, such as disorders of the nervous, respiratory, cardiovascular, renal, hepatic, endocrine system and the gastrointestinal tract;
	- Systemic autoimmune diseases or connective tissue diseases requiring treatment with systemic glucocorticosteroids, cytostatics or penicillamine;
	- Pregnancy or breastfeeding. Women planning a pregnancy during a clinical trial; women who do not use adequate methods of contraception;
	- The inability to read or write, failure to understand and follow research protocol procedures.
