10.1.2. Significance of Licensed Veterinary DNA Vaccines for Human DNA Vaccines

The licensure and the immunogenicity of the equine WNV vaccine are significant for human DNA vaccine efforts. The first reason is that scientists have often stated that DNA vaccines are not very good at inducing antibodies, yet this DNA vaccine induced neutralizing antibodies of sufficient titer for protection and licensure in horses. Also significant is that these antibodies were made in horses. Frequently, the lack of potency of DNA vaccines in human trials was considered to reflect the size of humans compared to the usual small pre-clinical animal models.
