**5. Conclusions**

The further studies of these effects are necessary. As far as we know, no systematic studies of blips in vaccinated patients have been performed before. The measurement of the magnitude of spontaneous increases of viral load could become the part of monitoring the results of immunotherapy of HIV-infected patients in the future.

In conclusion, we demonstrated safety of the candidate DNA vaccine in HIV-infected patients receiving ART, and detected unusual blips effects in vaccinated individuals, which may be of interest for the future studies.

**Author Contributions:** Conceptualization, A.P.K. and B.M.; methodology, E.A., R.A.-S., V.P., O.Z., and N.V.; validation, E.A., V.P., O.Z., and N.V.; formal analysis, E.A., V.P., and O.Z.; investigation, E.A., V.P., and O.Z.; resources, S.V. and A.M.; data curation, V.P., O.Z., and N.V.; writing—original draft preparation, E.A.; writing—review and editing, A.P.K.; visualization, E.A.; supervision, A.P.K.; project administration, A.P.K.; funding acquisition, A.P.K.

**Funding:** This research was funded by The Ministry of Industry and Trade Russia, government contract number 13411.1008799.13.160.

**Acknowledgments:** We wish to thank all trial participants for their devotion to the project.

**Conflicts of Interest:** The authors declare no conflict of interest.
