*2.2. Methods*

The electronic drug–drug interactions (DDIs) checking platform Lexicomp ® was used to evaluate patient medication regimens for pDDIs. The Lexicomp ® (Wolters Kluwer Health Inc. Riverwoods, IL, USA) database system provides accurate information about the risk, type, mechanism, and pattern of distribution of pDDIs. It also gives recommendations on how to prevent and manage DDIs if they occur. This software identifies and classifies pDDIs into five types according to the degree of clinical significance. Type A: no known interaction, Type B: minor or mild interaction, Type C: moderate or significant interaction, Type D: major or serious interaction, and Type X: contraindication or avoid combination.
