2.8.1. Animals

Male Sprague-Dawley rats (9 weeks, weighing 300 ± 50 g) were purchased from Koatech (Pyeongtaek, Korea). The rats were acclimated in the Animal Laboratory (Gyeongsang National University) under controlled condition of temperature (between 20 and 23 ◦C) and humidity (50% ± 5%) and allowed free access to food and water for 7 days. All rats were allowed to recover for 1 day after cannulation into the carotid artery. The rats were fasted for 12 h with free access to water, before the pharmacokinetic experiments.
