**5. Conclusions**

Liver growth factor is an albumin–bilirubin complex that exhibits remarkable neuroprotective, anti-inflammatory, and anti-oxidant activities in several models of neurodegenerative diseases. In the experimental model of AD used in this study (APPswe mouse), chronic LGF treatment reduced Aβ and phospho-Tau protein levels which are the main neuropathological features associated to the disease. LGF also reduced microglia and astroglia cell reactivity and modulated the expression of ASC CD36 and Nrf2 which are proteins involved in the regulation of inflammatory and oxidative processes. Because these beneficial effects correlated with an improvement in the cognitive deficits observed in the APPswe mice, we may consider LGF as a potential new therapeutic factor for AD.
