*4.3. Morris Water Maze (MWM)*

From the 17th day after the treatment with Bean-PS, the Morris water maze test was performed for 5 days. The black, plastic pool used in the Morris water maze test measured 200 cm in diameter and was filled to a depth of 35 cm with clear water maintained at 23 ± 2 ◦C. It was inserted in a submerged platform using external cues around the pool and within the behavioral room. For behavioral analysis, a personal computer was used to assort a charge coupled device (CCD). A probe test was run after the last trial on Day 4. In the experiment, the rats were exposed to an acquisition trial on each of 4 consecutive days. On Day 5, they were also trained in retention tests. The rats were allowed to search for the platform for 180 s during the acquisition test. On Day 5 of the retention test, the rats underwent a 1 min probe trial, in which the platform was eliminated from the pool. Probe trials were run at 1 min intervals. The animals in the performance test of each water maze trial were evaluated with a personal computer during the behavioral analysis (S-mart program, Barcelona, Spain).
