*4.8. Statistical Analysis*

The data obtained represent the mean with standard deviation. Differences among means were statistically analyzed using the two-way ANOVA test, followed by Bonferroni post-hoc tests. Statistical significance was considered at *p* < 0.05.

**Author Contributions:** H.Y.J., W.K., K.R.H., M.S.K., T.H.K., H.J.K., S.M.N., J.Y.C., Y.S.Y., D.W.K., D.Y.Y. and I.K.H. conceived the study. H.Y.J., D.Y.Y. and I.K.H. designed the study and wrote the manuscript. H.Y.J., W.K., K.R.H., M.S.K., T.H.K. and S.M.N. conducted the animal experiments. H.J.K., J.Y.C. and D.W.K. conducted

biochemical experiments. S.M.N., J.Y.C., J.H.C., Y.S.Y. and D.W.K. participated in designing and discussing the study. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by the Promising-Pioneering Researcher Program through Seoul National University (SNU) in 2015 and by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2019R1A2C1005440). In addition, this study was partially supported by the Research Institute for Veterinary Science of Seoul National University.

**Conflicts of Interest:** The authors declare that they have no competing interests.
