*4.1. Ethics Statement*

The present study was performed in accordance with the protocols of the Guidelines for the Use and Care of Laboratory Animals, allowed by the National Institutes of Health. Animal studies were conducted in accordance with the guidelines of the Committee on Animal Use for Study and Education at Hallym University (protocol # Hallym-2018-32; Data of approval: July 19,2018). We sacrificed mice under isoflurane anesthesia to minimize any pain and suffering.
