*4.2. Experimental Animals*

The present study used 2–3 month old adult male C57BL/6J mice (20–25 g, DBL Co., Chungcheongbuk-do, Eumseong-gun, Korea). The mice were housed three to four mice per cage under conditions of sustained temperature (20 ± 2 ◦C) and humidity (55% ± 5%). Animal room lights were managed automatically, turned on and off in a 12 h cycle (on at 6:00 a.m. and off at 6:00 p.m.).
