**6. Patents**

US 8,642,551 B2, 4 February 2014 CE, num. 09732019.6-1456, Ref. EP-883, April 2015 US 14/140.014, 26 May 2015

**Author Contributions:** Experimental Design, R.G.-G., J.P., D.R., M.J.C. and E.B.; performed the experiments, R.G.-G., J.P., M.V.-M., D.R., A.G., M.J.C., G.M.U.d.A. and E.B.; data Analysis: R.G.-G., M.J.C., D.R., A.J.E. and E.B. paper writing, R.G.-G., D.R., M.J.C. and E.B. All authors have read and agreed to the published version of the manuscript.

**Funding:** R.G.-G. was the recipient of a Research Supporting Staff Grant Contract (Spanish Health Research Fund (FIS)).

**Acknowledgments:** We are grateful to Miriam Novillo Pérez for technical help. We also thank the technical help provided by the Confocal Microscopy Unit of the Ramón y Cajal Institute for Health Research (IRYCIS). Our group also wants to thank Juan José Díaz Gil, who passed away on 4 November 2016, for the discovery of the Liver Growth Factor and for his exceptional dedication to pursuing knowledge about its effectiveness against neurodegenerative diseases. He will always be our great mentor and dear friend.

**Conflicts of Interest:** The authors declare no conflict of interest.
