*2.1. Temporal Changes of PGC-1*α *Expression in the Hippocampal CA3 following Status Epilepticus*

Temporal changes of PGC-1α expression in the right hippocampal CA3 region were examined following status epilepticus. After unilateral microinjection of kainic acid (KA; 0.5 nmol) into the left CA3 subfield, *pgc-1*α mRNA expression exhibited a significantly incremental change in the right hippocampal CA3 area 1 h after the elicitation of prolonged seizure activities, followed by a progressive decrement that returned to base line at 24 h (Figure 1a). For detection of the PGC-1α protein level, western blot analysis also presented a significant augment of PGC-1α protein in the right hippocampal CA3 subfield 1–24 h after the status epilepticus induced by KA (Figure 1b).
