**4. Conclusions**

In conclusion, a simple and effective strategy has been designed and proved for the surface modification of cotton textiles with multi-function responsiveness. The multi-function modified cotton fabric showed obvious temperature- and pH responsiveness behavior and antibacterial activity. The swelling ratio decreased significantly under the increasing temperature to the LCST of the hydrogels. The low values of equilibrium swelling ratios appeared at about pH 4.0 and 8.0. This is due to the salting-out effect and the isoelectric point (PI) of SS. The bacterial decline of multi-function modified cotton textiles against *E. coli* and *S. aureus* was all above 89%. Through the different combinations of textiles and smart polymers via electrospinning technology, the strategy shows robust advantages for the preparation of textiles with multi-function responsive properties. Moreover, this is also a simple, rapid and green environmental protection method for the fabrication of multi-functional fabrics. This study may provide the strategy of modified fabrics that can possess environmentally responsive or stimuli-responsive properties and that are supposed to be prospective materials, especially in smart and functional textile applications.

Here, this study is just a first step for the preparation of smart fabrics with nanofibers as a finishing technology. However, we would perform comprehensive functional testing for the real applications. Other applications of sericin/PNIPAM-based nano-modified cotton textiles such as mechanical properties, comfort capabilities and biocompatibility testing, and cell cytotoxicity tests will be shown in the following manuscripts.

**Author Contributions:** Conceptualization, J.G. and Y.-H.L.; methodology, J.L.; experimentation, J.L., B.-X.W., D.-H.C., and Z.-M.L.; date analysis, J.L. and L.-H.L. supervision, J.L., J.G. and Y.-H.L. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by the National Natural Science Foundation of China (grant numbers: 51773024 and 51873084), the Liaoning Province Department of Education fund item (grant numbers: LNSJYT201901 and LNSJYT202006 and LNSJYT202022), the Natural Science Foundation of Liaoning (grant numbers: 2019JH8/10100047 and 2019-ZD-0533), and the Science and Technology Innovation Fund Project of Dalian (2019J12SN71). The Innovation Team Foundation of Liaoning (grant number: LT2017017).

**Institutional Review Board Statement:** Not Applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Data is contained within the article.

**Conflicts of Interest:** The authors declare no conflict of interest.
