4.6.1. Animals

The biological experiments were carried out on outbred and C57BL/6 male mice housed in standard environmental conditions (room temperature, 12 h light/dark cycle). The animals had free access to standard pellet diet and water ad libitum. All experimental procedures were approved by the Local Bio-Ethical Committee of Medicine Chemistry Department of Novosibirsk Institute of Organic Chemistry SB RAS in accordance with European Communities Council Directive 86/609/EEC.
