*2.6. TRIOBP-1 in Other Diseases*

While TRIOBP-1 is not generally considered to have a significant role in hearing loss, unlike TRIOBP-4, it should be noted that TRIOBP-1 is expressed in the stereocilia of the inner ear [20]. Here, it binds to the hearing-related protein Pejvakin, with over-expression of TRIOBP-1 causing Pejvakin to form aggregates [20]. There have also been reported missense mutations within *TRIOBP-1* in patients with hearing loss [47,48] (Table 1), however, these would also affect longer splice variants of *TRIOBP*.
