*3.5. TRIOBP-4 Mutations in Other Illnesses*

In addition to hearing loss, rare missense mutations in *TRIOBP-4* (and longer splice variants) have also been detected in a patient with multiple sclerosis (A322S mutation) [63] and in a patient with developmental delay, visual impairment, muscle weakness, hypotonia, clinodactyly, and mild hearing impairment (R1078C mutation) [64].
